As we close out the first month of 2020, we wanted to share some highlights from 2019.  Here is VetStem’s 2019 year in review.

In 2019:

• VetStem provided stem cell processing services for over 800 patients.

• We trained over 60 new veterinarians to use VetStem Cell Therapy.

• Over 80 veterinarians began using VetStem services and/or products for the first time.

• We processed fat tissue from more cats in 2019 than we have in any one year out of the entire ten years that we’ve been providing this therapy for cats.  This is likely due to the launch of our Clinical Research Programs including feline Chronic Kidney Disease, Gingivostomatitis, and Inflammatory Bowel Disease.

• We provided stem cell services for the first bear to be treated with VetStem Cell Therapy.

• Along those same lines, we donated a platelet therapy kit for the treatment of our first kangaroo.

• VetStem was featured in an award-winning documentary, Animal Pharm: Where Beasts Meet Biotech.

• VetStem entered the pet cancer field with new work on a developing cancer therapy. 

• And perhaps most important, in 2019, VetStem announced the launch of our human stem cell company, Personalized Stem Cells, Inc. who is currently conducting an FDA-approved clinical trial for the treatment of knee osteoarthritis with stem cells.

WHEW!  It was a big year for us!  Thank you to our veterinary colleagues and pet owners who have entrusted us with the processing of your patient’s and pet’s stem cells.  Here’s to a great 2020 for everyone! 

At just four months old, Tucker, a Labrador retriever, was limping and lame.  At one year of age, he was diagnosed with bilateral hip and elbow dysplasia.  His veterinarian prescribed him pain medications as well as nonsteroidal anti-inflammatories (NSAIDs).  After four years of continuous medication and restricted physical activity, Tucker’s owners were introduced to VetStem Regenerative Cell Therapy as a potential treatment option for osteoarthritis in his hips and elbows.

To begin the process, Dr. Glenn Behan of Barnegat Animal Clinic collected Tucker’s fat tissue and sent it off to the VetStem laboratory in January 2019. Once received, VetStem lab technicians processed the fat to extract Tucker’s stem and regenerative cells for injectable stem cell doses. Tucker’s stem cell injections were sent back to Dr. Behan and, approximately 48 hours after the initial fat collection, Tucker received one injection into each hip and each elbow.

At just one month post stem cell therapy, Tucker’s owners noticed his energy level was up, he could get up and down with more ease, and stairs were easier to climb. After approximately six weeks, Tucker could walk further distances and his limp subsided. His owner stated, “He was able to actually run on the beach and through the surf for the first time without pain. There was almost a hop in his step which we had never seen before.”  In a 90-day follow up survey, Tucker’s owner reported that he was able to discontinue his pain and anti-inflammatory medication and his quality of life was significantly improved.

Approximately seven months post stem cell therapy, Tucker continued to do great. With his increased activity, he lost ten pounds and was getting around so much better. He would go on walks, up and down stairs and even began jumping on the bed, which he could not do before. He also played a lot more with his little brother. At that point in time, he continued to not require pain or anti-inflammatory medication.

It has been approximately one year since Tucker’s stem cell therapy and he has not required additional stem cell treatments.  Like Tucker, some dogs are able to reduce or discontinue pain and/or anti-inflammatory medications after receiving VetStem Regenerative Cell Therapy.  It is important to point out that NSAID use can lead to gastrointestinal upset and organ damage, which is why most veterinarians advise against long-term use of NSAIDs.

If you think your dog may benefit from stem cell therapy, speak to your veterinarian or contact us to receive a list of VetStem providers in your area.

At VetStem, one of our goals is to educate pet owners about the prevalence and potential severity of osteoarthritis (OA) in our pets.  Osteoarthritis is a degenerative disease that can be debilitating.  It has even been identified as the number 2 reason for euthanasia.  Though 1 in 5 dogs in the U.S. are affected by OA, there are some steps you can take to potentially reduce or delay the symptoms of OA in your pet. 

In a previous blog, we shared some steps you can take to help reduce or delay the symptoms of OA in your pet.  One of those steps is to provide your pet with regular exercise.  While pets require varying amounts and different types of exercise, your veterinarian can help you to develop an exercise routine tailored specifically to your pet.

Since January is Walk Your Pet month, we thought it important to highlight the potential effects that regular walks can have on your pet’s joint health.  Colorado State University College of Veterinary Medicine states, “Regular physical activity is paramount in the treatment of osteoarthritis both in humans and animals.  A lifestyle of regular activity that is moderated away from intermittent extremes of exercise and activities to which the pet is not conditioned is essential.  Ideally, multiple shorter walks are better than one long one.  The same activity every day (or slightly increasing if tolerated) is ideal.” 

According to the Arthritis Foundation, walking comes with several benefits which may lead to healthier joints including muscle strengthening, joint fluid circulation, and weight loss.  Weight loss is an important factor when it comes to managing pain and lameness associated with osteoarthritis.  One study found that weight loss significantly decreased lameness in obese dogs with OA.  If you’re concerned that your pet may be overweight, you can refer to this blog or contact your veterinarian. And don’t forget, cats get OA too!  Cats with OA may also benefit from exercise.  Speak to your veterinarian about the best way to exercise your cat.

For our first blog of the new year, we thought we would try something a little different.  This week, we have a guest blog submitted by dog owner Virginia regarding her dog Ember and her stem cell story.  Ember received VetStem Cell Therapy after she was diagnosed with elbow dysplasia.  She’s feeling much better and…well, we’ll let Ember tell her story…

Hi,

My name is Ember and I am a 4-year-old Newfoundland. I’m writing this because I was asked to tell my story.

In my family we are first and foremost companions to our people, we live side by side with them.  But we have other jobs as well.  One is we do a lot of social and therapy work to bring smiles to people.  Our other career is to be “show dogs.”  Being social dogs, we like both our jobs.

But things changed for me when we discovered that I had bilateral elbow dysplasia confirmed by OFA x-rays.  Sometimes I would limp a bit, other times not.  When I was 2 and 1/2, I started limping and did not stop for months.  That was not fun, and I did not feel like playing with all my friends at home (I have a big family). 

Then on “My Lady’s” birthday her best friend (and my first home) gave her the gift of stem cell therapy for me.  She seemed excited; I did not know what she was talking about at all.  I just go with the flow so I wagged my tail. 

Before stem cell therapy, I was lame and really didn’t play as much as I wanted to.  It is over 5 months now from my injections and I feel a lot better!  I am my happy self, I play with my friends, even the puppy.  I am more active and can get in bed to sleep with my people at night.  I am not lame anymore.  My movement is so much better and I am pain free. 

I am very grateful to My Lady’s friend for giving such a thoughtful gift.  It has made a huge difference for me.  I want to say thank you to all the people who worked hard so this option could be made available for us dogs. 

Life is better with stem cells.

Love,

Ember

VetStem recently attended and exhibited at the annual American Association of Equine Practitioners conference.  The convention brings equine veterinarians and veterinary professionals together from across the United States to what is the world’s largest continuing education event dedicated to equine practice.

VetStem sponsored a presentation by Dr. Roland Thaler, who has been utilizing VetStem Cell Therapy for over ten years.  In his presentation, Dr. Thaler discussed an equine patient, Mac, who was treated with VetStem Cell Therapy for non-responsive uveitis.  Uveitis is characterized by inflammation of the uveal tract of the eye and can be a one-time episode or recurrent.  Recurrent uveitis can lead to permanent damage and even blindness.

Though the cause of recurrent uveitis is unclear, there is evidence to suggest it may be immune-mediated.  Stem cells have demonstrated the ability to reduce inflammation and to modulate the immune system.  Preliminary in-vitro and clinical case series results demonstrate safety and that stem cells may be effective in controlling recurrent uveitis including one where three out of four horses had a favorable response to treatment with stem cells.  

In Mac’s case, his uveitis was non-responsive, meaning his symptoms could not be managed with traditional therapies.  Dr. Thaler recommended treatment with VetStem Cell Therapy.  Mac was treated in July 2019 and the cells were administered via intravenous injection as well as subconjunctival.  Dr. Thaler reported that 14 days after treatment, Mac had marked improvement of comfort and his medications were able to be reduced.

Mac received a second treatment with stem cells in early October 2019.  Despite his initial improvement, Mac’s condition worsened and he was retired from competition due to visual impairment. 

Dr. Thaler noted that Mac tolerated the subconjunctival injections remarkably well.  Mac’s initial response to treatment was promising leading Dr. Thaler to recommend treating recurrent uveitis as early in the disease process as possible.    

It’s December and while most are excited about the holiday season, we at VetStem are excited about cats!  We have more than a few cat lovers at VetStem, Sue and Kristi, to name a few.  We figured, what better month than this to share new and exciting information about regenerative medicine for felines?!

You may remember some of our previous blogs about stem cell therapy for felines.  If you need a refresher, check out this recent post: Stem Cells for Cats: An Overview.  To summarize, veterinarians are using VetStem Cell Therapy to treat a number of conditions in cats.  In addition to osteoarthritis, the most commonly treated diseases include chronic kidney disease, inflammatory bowel disease, and gingivostomatitis.

Veterinarians have also used our small animal platelet therapy kit for orthopedic conditions in cats.  Veterinary Platelet Enhancement Therapy (V-PET™) is used by veterinarians to collect and concentrate a patient’s platelets.  The platelet concentrate can be injected into joints, injured tendons and ligaments, as well as chronic wounds. 

One of our frequent users, Dr. Jeff Christiansen, recently treated a cat who had an FHO (surgery to remove the ”ball” of the hip ball-and-socket joint) utilizing V-PET™.  The cat suffered a fracture in his hip and platelet concentrate was injected into the joint after surgery.  Typically, cats will show signs of complete recovery from an FHO procedure at approximately six weeks post-surgery. In this cat’s case, he was comfortable and walking around with good range of motion at four weeks post-op. While the injury required surgical intervention, the addition of V-PET™ into the surgical site may have led to expedited healing.

Some more exciting news about cats is actually about cheetahs!  Dr. Matt Kinney of the San Diego Zoo Safari Park recently presented information at the American Association of Zoo Veterinarians conference regarding working with VetStem to treat a couple of cheetahs.  We hope to share more about this soon!  This is not the first time that VetStem has provided cell services and on-site consultation for the treatment of exotic animals.  A Sun Bear named Francis was another recipient of such services.

Follow our blog to keep up with new research and developments.

In this week’s veterinarian highlight, we’d like to introduce you to veterinary surgeon and VetStem user Dr. Adam Gassel.  Dr. Gassel practices at Blue Pearl Pet Hospital in Irvine, California.  He received his DVM from Purdue University in 1991 and pursued an internship with Animal Specialty Group in Los Angeles.  He then completed a surgical residency at the University of Tennessee, Knoxville and became a board-certified veterinary surgeon in 2007.

Dr. Gassel’s surgical interests include TPLO (a surgery to stabilize the knee), portosystemic shunts, surgical oncology, and minimally invasive procedures, particularly arthroscopy and laparoscopy.  Dr. Gassel frequently incorporates VetStem Cell Therapy into his orthopedic surgeries for things like joint dysplasia/osteoarthritis and Fragmented Coronoid Process.  He has treated 125 patients utilizing VetStem Cell Therapy and is part of the VetStem Centenniel Club.

We recently asked Dr. Gassel a few questions about his use of VetStem Cell Therapy.  See his answers below regarding his specific experiences.

Why do you find VetStem Cell Therapy to be a valuable addition to your practice?

VetStem Cell Therapy is a valuable tool because of the ability of regenerative medicine (stem cells) to treat acute and chronic pain associated with tissue trauma and chronic degenerative joint disease.  We perform a variety of surgical procedures at our practice and I have been using stem cells primarily and as an adjuvant for my patients over the past 12 years.  VetStem Cell Therapy is a natural alternative to traditional medications used to treat chronic osteoarthritis, especially for patients that cannot tolerate the use of non-steroidal anti-inflammatory drugs (NSAIDs).  We can stabilize a torn cranial cruciate ligament and remove cartilage fragments from a damaged elbow, but we cannot replace the damaged cartilage that can result from the initial injury.  In my opinion, this is when regenerative medicine can play a vital role in treating chronic pain and inflammation associated with these injuries.  Ongoing arthritis can be a debilitating and frustrating disease for our patients and their families.  Regenerative stem cell therapy provides us with a safe and efficacious way of treating these patients to improve their quality of life.    

As a surgeon, do you primarily recommend stem cell therapy in addition to surgery or in lieu of surgery?  Please explain your answer.

This determination is made on a case by case basis.  There are a variety of procedures in which stem cell therapy is used in combination with surgery to provide an optimal outcome.  There are certainly cases in which stem cell therapy is used in lieu of surgery mostly due to patient factors.  However, I have also been educating clients on the benefits of stem cell therapy and to consider taking advantage of the Canine StemInsure program if their pet is under anesthesia for routine prophylactic surgeries (stem cells to be stored for future use).

What advice would you give to pet owners considering stem cell therapy for their pet?

Stem cell therapy is a safe and effective way to address both acute and chronic pain caused by a variety of diseases seen in our patients.  Adipose tissue (fat) provides a rich source of stem cells that can easily be harvested with a quick and safe surgical procedure.  Once isolated and re-administered to the patient, current literature supports the ability of stem cells to reduce inflammation and pain while helping to re-build bone and soft tissue.  Pet owners should understand that there are injuries and diseases that cannot be fixed with stem cell therapy alone and should keep an open mind when consulting with the specialist.  Overall, this “cutting-edge” therapy can lengthen and improve the quality of life of their pet. 

There you have it!  Thank you Dr. Gassel for taking the time to answer our questions!  If you are located in the Irvine area and looking for an experienced stem cell provider, contact Blue Pearl Irvine for a consultation with Dr. Gassel.

In our blog about translational medicine, we announced that VetStem was featured in an award-winning documentary, Animal Pharm: Where Beasts Meet Biotech.  The film was included in the Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it received the award for Best Nature and Animals Film.

The documentary focuses on regenerative veterinary medicine as a means of improving the quality of life for domestic and wild animals and heavily features VetStem, including an interview with VetStem Founder and CEO Dr. Bob Harman.  Dr. Harman explains that when he first conceived of and formed VetStem, he was called “crazy.” Over time however the thinking has evolved so that regenerative medicine is now regarded as a legitimate and valuable tool for veterinarians.

We recently received the exciting news that the film will be featured in the Palm Beach International Mini Movie and Film Festival on December 9^th in Palm Beach, Florida.  Not only will the film be featured, the producers will also be presented with the award for Best Documentary!  Congratulations to everyone involved in the making of the film.

We are proud to be a part of this film and believe that it provides a great service to the public by providing legitimate education about cell therapy in the veterinary field and how this can assist the field of human stem cell therapy.    

A few weeks ago, our sales and marketing team was at the American Association of Feline Practitioners conference in San Francisco, CA.  So, we thought it an appropriate time to discuss stem cell therapy for cats.  This blog will give you an overview of some of the conditions that veterinarians have treated with VetStem Cell Therapy.

Veterinarians have used VetStem Cell Therapy to treat a variety of conditions in their feline patients, one of which is osteoarthritis.  Though we primarily think of dogs when it comes to osteoarthritis, cats are not immune to the disease.  Their symptoms however may be more subdued or even unnoticeable to their owners- cats tend to be masters at hiding their illnesses.  Some signs to look out for include a decreased activity level, an inability to jump to high places, and missing the litterbox.  In addition to osteoarthritis, veterinarians have used VetStem Cell Therapy to treat cruciate ligament injuries and fractures in cats.

Veterinarians also use VetStem Cell Therapy for the treatment of internal medicine and immune-mediated diseases in cats through our Clinical Research Programs.  A large population of VetStem’s feline patients have been treated for Chronic Kidney Disease.  Based upon data from a small number of feline patients treated with VetStem Cell Therapy, blood kidney values were slightly to moderately improved after treatment.  The goal of our current clinical research program for feline Chronic Kidney Disease is to gather additional data and to better understand the effects of stem cell therapy on these cats.

Two additional clinical research programs are for the treatment of feline Gingivostomatitis and Inflammatory Bowel Disease.  Gingivostomatitis is a painful disease that affects the mouth of cats and can lead to full mouth teeth extractions.  Two small studies conducted at the University of California Davis in cats with full mouth teeth extractions showed favorable results after receiving stem cell therapy for this condition. VetStem believes that stem cells may help without cats having to undergo full mouth teeth extractions.  Inflammatory Bowel Disease is a chronic gastrointestinal disorder which can cause diarrhea, vomiting, inappetence, and weight loss.  In a recently published paper, 5 out of 7 IBD cats that were treated with stem cells were significantly improved or had complete resolution of symptoms whereas the 4 control cats had no improvement.  Since this disease can also affect dogs, VetStem is evaluating the use of stem cells in both species with this condition.

Though this is not an all-inclusive list, the above conditions are those that are most commonly treated in cats with VetStem Cell Therapy. As always, if you think your cat may benefit from stem cells, speak to your veterinarian or contact us for a list of VetStem providers in your area.

It is officially November, which happens to be Senior Pet Month!  We wanted to highlight senior pets in this week’s blog as we all know that senior pets may be more at risk of developing osteoarthritis.  While dogs and cats of all ages may develop osteoarthritis, studies have indicated that senior dogs are more often diagnosed with osteoarthritis, in part due to the age-related break down of joint tissues such as cartilage, ligaments, and bone.

There is also speculation that senior pets are more often diagnosed with osteoarthritis because symptoms become more prevalent as the disease worsens.  Therefore, owners are more likely to notice symptoms such as limping and stiffness as their pet ages, which often leads to a trip to the veterinarian for diagnosis/treatment.

Maverick, a Golden Retriever, was adopted at 8 years old with osteoarthritis.  Fortunately, his new parents sought VetStem Cell Therapy for his condition and he experienced an improved quality of life.

It is important to note however that dogs and cats may develop osteoarthritis at any age.  For instance, if a dog is born with joint dysplasia (malformed joints), he is more likely to develop osteoarthritis at a younger age than a dog born with properly formed joints.  One example is Jack who was showing symptoms of osteoarthritis before he was even a year old.

The good news is, VetStem Cell Therapy has shown to help pets, both young and old, with osteoarthritis.  Stem cells have been demonstrated to regenerate joint tissues and reduce inflammation.  They also have pain blocking mechanisms that may lead to increased comfort for painful pets.  If your pet, no matter their age, has been diagnosed with osteoarthritis or is showing signs of the disease, speak to your veterinarian about the possibility of treatment with VetStem Cell Therapy.  Or contact us to receive a list of VetStem providers in your area.