VetStem recently launched two FDA-reviewed platelet-rich plasma (PRP) products: PrecisePRP™ Canine and PrecisePRP™ Equine. PrecisePRP™ is a freeze-dried off-the-shelf PRP unlike any platelet-rich plasma currently on the market. The primary benefits of PrecisePRP™ include ease of use and consistency. With PrecisePRP, you no longer have to draw blood and process it to obtain the PRP. You simply reconstitute and inject. Additionally, PrecisePRP™ provides a consistent dose of PRP so you know exactly what you’re injecting every single time.

After a few months on the market, numerous veterinarians have begun to routinely incorporate PrecisePRP™ into their practice. We recently spoke with board-certified veterinary surgeon and long-time regenerative medicine provider, Dr. Jeff Christiansen, to learn about his use of platelet-rich plasma and to hear his thoughts after using PrecisePRP™. Below, you will find a brief Q&A followed by a link to the video interview, which goes into more depth.

What are the most common injuries/conditions you treat with PRP?

I use PRP primarily in conjunction with surgeries and/or in combination with stem cell therapy. I most commonly use it for cruciate injuries, either with stem cell therapy and/or with surgery (TTA vs. extracapsular). I also use it with medial patellar luxation +/- stem cell therapy. I have used it in cases of hip dysplasia in combination with stem cell therapy. Other arthropathies I have used PRP for include elbow, shoulder, carpus and, less commonly, tarsus. I frequently use PRP with fracture repairs, with both long bone and joint fractures. I also use it for tendon/ligament injuries, such as common calcaneal/Achilles, collateral, etc. And lastly, any reconstructive surgery, tumor removal, resection of inflamed/infected tissue, etc.

What do you like most about PrecisePRP compared to previous PRP kits you have used?

PrecisePRP requires less work and time. Certainly, PrecisePRP does not require a clean blood draw, which is harder in some small patients, nor is there the risk of the sample clotting and wasting/losing a whole kit. When you take a centrifuge out of the equation, you don’t have to worry about matching/balancing/spinning or technical challenges with the filtration kits. PrecisePRP is also nice with a small or an anemic patient so you don’t have to take their blood.

How do you select patients for PRP?

I recommend PRP in all of the cases listed in #1. For ortho cases, a lot of owners find stem cell therapy cost prohibitive, but they want to do something to help accelerate healing and minimize arthritis, so they do PRP.

Click the image below to watch the full interview where Dr. Christiansen goes into depth about his use of PRP and why he likes PrecisePRP!

July 21^st is World Collie Day so we thought it fitting to share Casey’s VetStem success story. Casey is a Rough Collie who began experiencing symptoms of Inflammatory Bowel Disease when he was around 4 months old. At first, he was not eating regularly. This was followed by frequent bouts of diarrhea and vomiting. After trying multiple diets and medications with no success, numerous diagnostics including X-rays, bloodwork, ultrasound, and biopsies of his GI tract led to a diagnosis of Inflammatory Bowel Disease (IBD).

IBD is a gastrointestinal disease that can affect both dogs and cats. It is characterized by inflammation of the intestines and can cause vomiting, diarrhea, reduced appetite, and weight loss. IBD can be a frustrating disease because a definitive diagnosis can be time-consuming and costly, traditional treatments are life-long and can be complex, and the animal often continues to experience symptoms of the disease despite treatment.

Though Casey was on a special diet and multiple medications, his symptoms were minimally controlled. This went on for about three years until his bloodwork revealed elevated liver enzymes, which was a result of his steroid medication. It was at this time that his veterinarian recommended treatment with VetStem Cell Therapy.

Stem cells have demonstrated the ability to down regulate inflammation, modulate the immune system, and repair damaged tissue. Multiple animals have been treated with stem cell therapy for IBD and experienced a relief in symptoms and an improved quality of life. After some research, Casey’s owners agreed to move forward with VetStem Cell Therapy.

To begin the process, Casey had fat collected from his abdomen in a minimally invasive anesthetic procedure. The fat was aseptically packaged and shipped to the VetStem processing laboratory. Lab technicians processed the fat to isolate and concentrate the stem and regenerative cells contained therein. Therapeutic doses were then prepared for treatment.

Over the course of 10 months, Casey received 5 separate intravenous doses of his own stem cells. According to his owner, his symptoms improved greatly. He began interacting more and playing with his family and other dogs. He started rolling over for belly rubs, which he had not done in the first 3 years of his life. His appetite improved and he was able to get off all but one of his medications, including being completely off steroids. He has occasional IBD flare ups but nothing to the degree he experienced previously.

Approximately 15 months after his 5^th stem cell treatment, Casey received a 6^th intravenous dose (along with intra-articular doses to treat a few arthritic joints) and hasn’t required additional treatments for over year now. He does, however, have numerous doses left in his stem cell bank, should he ever require future treatments.

If your pet has Inflammatory Bowel Disease, speak to your veterinarian or contact us to find a VetStem provider near you.

Casey

A few weeks ago, we discussed VetStem’s extensive work with numerous exotic species. One example is a Sichuan Takin (rhymes with rockin’) named Xing, who resides at the Saint Louis Zoo. According to the Zoo’s website, Takin are an antelope-like goat ranging in weight from about 500 to over 800 pounds depending on their sex. They are native to China and reside in mountainous bamboo forests.

Sadly, the Sichuan Takin wild population is diminishing, and they face a high risk of extinction in the wild. Fortunately, zoos such as the Saint Louis Zoo participate in the Species Survival Plan for Sichuan Takin, a cooperative breeding program that helps ensure a healthy population of animals.

When Xing was young, he sustained an injury to both his carpal (wrist) joints which predisposed him to arthritis. The Zoo’s animal care and veterinary teams monitored Xing closely for the development of arthritis. Xing was eventually diagnosed with arthritis, and his symptoms included a stiff gait and decreased activity. One of the Zoo’s staff veterinarians, Dr. Rachel Ferris, reached out to us to inquire about helping Xing with stem cell therapy and of course we said yes!

Stem cells have the ability to down regulate inflammation and pain. They have also shown to help regenerate joint tissues, such as damaged cartilage. Just like the thousands of arthritic dogs, cats, and horses that have experienced an improved quality of life as a result of treatment with VetStem Cell Therapy, we believed stem cells could help Xing.

Over the last year, Xing has received three treatments with mesenchymal stem cells. According to Dr. Ferris, his activity level has improved significantly since starting treatment. We love to hear this news! Xing recently celebrated his 8th birthday and continues to thrive.

Xing

As most of our readers know, VetStem Cell Therapy is primarily used to treat orthopedic conditions in dogs and horses. Cats, on the other hand, frequently receive stem cell therapy for indications such as renal disease, inflammatory bowel disease, and gingivostomatitis. One such cat, a young Siamese named Finn, received VetStem Cell Therapy for gingivostomatitis when he was approximately one year old.

We’ve shared Finn’s stem cell success story in a previous blog. But to sum it up, Finn was diagnosed with gingivostomatitis at just five months old. Gingivostomatitis is a debilitating condition characterized by chronic inflammation of the affected cat’s gums. It can be very painful and lead to inappetence, reduced grooming, and weight loss. Unfortunately, there is no cure for this disease. Common treatments include lifelong medical management with antibiotics, steroids, pain medications, and/or full mouth teeth extractions.

Finn’s owners tried several medications in an effort to improve his symptoms, but nothing worked. They were determined to not have all of his teeth extracted and were willing to do whatever it took. His veterinarian recommended treatment with VetStem Cell Therapy and just shy of his first birthday, Finn received stem cell therapy.

According to his owners, Finn responded well to the treatment. His owner stated, “[the stem cell treatment] seemed to improve and maintain his condition especially over time so that Finn is happy, healthy, and living a great life. We plan to administer cells every year or so to keep his condition manageable and hopefully keep him healthier too.”

Fast forward to the present, four years after his initial stem cell treatment, and Finn continues to do well! We recently received an update from his owner who stated, “Finn had his annual checkup recently and he’s doing great. He had some gingivitis but his stomatitis seemed to be under control. He had his annual teeth cleaning today (per his veterinarian’s recommendation) and is doing great otherwise!”

Stem cells have shown the ability to reduce inflammation and also help to modulate the immune system. This mechanism of action is particularly important for immune-mediated conditions such as gingivostomatitis. If your cat has gingivostomatitis, VetStem Cell Therapy may help. Contact us to receive a list of providers near you.

Happy National Dachshund Day! In this week’s VetStem blog, we’re sharing the stem cell success story about a Doxie named Floppy who was suffering from severe arthritis in his hips and knees. In a video his owner shared with us, Floppy showed extreme difficulty getting up from a down position and moved very slowly. His owner also stated that he limped and was very stiff.

Floppy was 8 years old when his veterinarian recommended treatment with VetStem Cell Therapy. To begin the process, his vet extracted fat from his abdomen during a minimally invasive anesthetic procedure. The fat was shipped to the VetStem laboratory where lab technicians extracted and concentrated Floppy’s stem and regenerative cells. Five stem cell injections were prepared and shipped to Floppy’s veterinarian for treatment. He received one injection into each hip, each knee, and an intravenous injection.

Floppy’s results were really remarkable. His owner stated, “We are extremely pleased with the results. The level of pain/stiffness decreased dramatically. It’s almost like he’s a puppy again! There is a night and day difference in his ability to move and perform everyday tasks.” His owner also sent a video of Floppy after the treatment with VetStem Cell Therapy and well…you just have to see it to believe it. Check out a short video detailing Floppy’s story here: https://www.youtube.com/watch?v=sJRUBYyDtqw

If you have a dog who suffers from arthritis, VetStem Cell Therapy may help. Speak to your veterinarian or contact us to receive a list of VetStem providers near you.

Next week is Take Your Pet to Work Week! And as most of you know, VetStem is no stranger to having our furry, four-legged companions in the office. But beyond the sheer cuteness overload, there are additional benefits to bringing your pet to work that you might not have considered.

First off, let’s talk about stress relief. We all know work can get a bit overwhelming at times, but having your pet by your side can work wonders for keeping those stress levels in check. Just a quick scratch behind the ears or a cuddle session during a coffee break can help to boost your mood. Plus, having a furry coworker can instantly lift spirits and provide some fun during the workday.

Bringing your pet to work isn’t just good for your mental health, it can also boost productivity and improve office morale. One study found that 90 percent of employees in pet friendly workplaces feel highly connected to their company’s mission, fully engaged with their work, and willing to recommend their employer to others. Additionally, more than three times as many employees at pet friendly workplaces report a positive working relationship with their boss and co-workers and are more likely to stay with a company long term. And let’s face it, who wouldn’t want to work in an office where adorable animals roam the halls?

Check out some interesting studies about pets in the workplace here. And be sure to grab the leash, pack some treats, and get ready to celebrate Take Your Pet to Work Week! Your furry friend will thank you, and your coworkers will too.

As June is National Zoo and Aquarium Month, we thought it fitting to discuss the work VetStem has done with exotic animal organizations across the United States. As most of you know, VetStem Cell Therapy is primarily used in dogs and horses to treat orthopedic conditions. We also do a lot of work with cats to treat alternative conditions such as chronic kidney disease and gingivostomatitis. But did you know VetStem Cell Therapy has also helped to improve the lives of several exotic species?

VetStem has worked with numerous zoos, aquariums, and exotic animal refuges to provide stem cell therapy for multiple species. One of our biggest exotic programs has been with elephants who are infected with a virus known as Elephant Endotheliotropic Herpesvirus (EEHV). EEHV is a lethal viral infection that can cause a highly fatal hemorrhagic disease. Stem cells have numerous mechanisms of action, including the secretion of molecules that are anti-viral. VetStem has provided stem cell doses to several zoos in the United States who had elephants with EEHV and has gathered some promising data. While there is still research to be done, we are optimistic that stem cell therapy may be a viable treatment option for elephants with EEHV.

We have also seen success using stem cells in a couple of bears. Francis is a sun bear from the San Diego Zoo that received VetStem Cell Therapy for arthritis in several joints. According to his keepers, Francis’ symptoms improved and he was climbing more after receiving stem cell therapy. Brody, a black bear in Florida, was a juvenile when he received VetStem Cell Therapy in conjunction with surgery for a condition that is similar to hip dysplasia in dogs. Dr. Jeff Christiansen, a board-certified veterinary surgeon and longtime VetStem proponent, performed his surgery and stem cell therapy. Check out a video of Brody from the Brevard Zoo to get more details about his story: https://www.youtube.com/watch?v=MGu4siQNNnU

VetStem has also been used in numerous aquatic species. We have provided cell therapy services for dolphins, whales, penguins, sea lions, sea turtles, and more. Aquatic animals have received stem cells for various conditions including arthritis, corneal conditions, and acute injuries such as this sea turtle who was injured by a propeller.

These are just a few examples of the many exotic species that have received VetStem Cell Therapy. We have provided stem cell services for over 60 species! As leaders in the field of regenerative veterinary medicine, we take our job very seriously when it comes to the research and development of innovative regenerative medicine treatments for animals and diseases that have minimal treatment options. Maintaining the health and well-being of endangered exotic animals is particularly crucial and has become a community effort, bringing together veterinarians, scientists, and those in the animal health field across the globe. We are happy to contribute to the mission and will continue our own research to develop potentially life-saving stem cell treatments for these animals.

Recently, the VetStem sales and marketing team attended two veterinary shows. One team was in Lexington, KY at the International Society of Equine Locomotor Pathology (ISELP) Proximal Forelimb and Neck Connection module while the other team was in Nashville, TN at the Fetch Nashville conference. At both shows, we were excited to announce that our platelet-rich plasma (PRP) products, PrecisePRP™ Canine and PrecisePRP™ Equine, have completed FDA review.

PrecisePRP™ is intended to provide a species-specific source of concentrated platelets in plasma for intra-articular administration and is unlike any PRP mechanical kit currently on the market. PrecisePRP™ is a freeze-dried, donor-derived (allogeneic) platelet-rich plasma product. Unlike mechanical PRP kits, PrecisePRP™ does not require a blood draw or centrifugation, nor refrigeration, making it a truly off-the-shelf product that is easy and convenient.

Perhaps more important is the uniformity and consistency that PrecisePRP™ provides with its unique patent pending manufacturing process. Each vial of PrecisePRP™ contains a consistent dose of 4 billion platelets per vial at a concentration of 500,000 platelets per microliter and is leucoreduced with less than 1500 white blood cells per microliter. Additionally, each lot is quality tested before release.

According to the FDA, PrecisePRP™ Canine and PrecisePRP™ Equine are the only FDA-reviewed PRP products for dogs and horses available to veterinarians. Both products underwent thorough evaluations by the Center for Veterinary Medicine that resulted in formal risk reviews. According to the FDA, “the developer of PrecisePRP properly identified and appropriately mitigated the potential risks associated with the product, and the FDA has no additional safety concerns.”

Understandably, veterinarians are very excited about these new products. PrecisePRP™ is not only easy, it’s also consistent, allowing veterinarians to know that the PRP they are injecting has been quality tested for sterility, platelet count, and potency. In providing a more consistent product and what is believed to be a therapeutic dose of PRP, the goal is to achieve more favorable outcomes. To learn more about PrecisePRP™, visit our website.

Platelet-rich plasma has been used in veterinary medicine for over 20 years. It is commonly used to treat musculoskeletal diseases and injuries such as osteoarthritis and injured tendons and ligaments. It has also been used topically for wounds and corneal ulcers as well as several other indications. The principle of PRP therapy is to accelerate lagging internal healing processes by amplifying the biological signals that would naturally occur when platelets aggregate at a site of injury. By concentrating platelets and releasing more of those growth factors than would naturally occur, the intended effect is to attract stem cells and other healing cells to stimulate local tissue repair processes.

Today is German Shepherd day so we thought we’d share a special VetStem success story about a bomb sniffing German Shepherd named Jax. Like many large dog breeds, German Shepherds are predisposed to hip dysplasia and arthritis. And unfortunately, Jax was diagnosed with the condition at a young age.

Hip dysplasia is a deformity in the ball and socket joint of the hip that eventually leads to osteoarthritis. It is a painful condition that can greatly reduce a dog’s quality of life. And of course, it affected Jax’s ability to perform on the job.

Jax’s veterinarian, Dr. Jeff Christiansen of Superior Veterinary Surgical Solutions, recommended treatment with VetStem Cell Therapy. Dr. Christiansen has been utilizing VetStem Cell Therapy for over a decade and has previously provided stem cells for working police dogs. To begin the process, fat was collected from Jax’s abdomen in a minimally invasive anesthetic procedure. The fat was processed at the VetStem processing laboratory to extract and concentrate the cells contained therein. Three injectable doses of Jax’s own stem cells were shipped to Dr. Christiansen for treatment. Jax received one injection into each hip and one intravenous dose.

According to his owner and handler, Jax responded well to the treatment. He stated, “Jax is a year and a half and, well, to say he’s a fantastic pup is an understatement. His limping is gone and he’s a typical GSD.” Jax has been maintained on a yearly intravenous injection of his stored stem cells for the past couple of years. Last we heard, Jax is rocking the bomb work! Way to go, Jax!

Jax

Many animals have received VetStem Cell Therapy without, or sometimes instead of, surgery. There are numerous cases where stem cells can help the body to heal naturally without having to undergo an invasive surgery. That being said, there are times when surgery is absolutely necessary. In these cases, VetStem Cell Therapy is great to use in conjunction with surgery to help improve and expedite healing.

Raven, an Italian Greyhound, was just a puppy when she got her front leg caught in a fence, resulting in a broken radius and ulna. The break required extensive reparative surgery, which included a steel plate and eight screws to anatomically reduce the bones and to prevent shortening and angular and/or rotational deformity. Fortunately, Raven was in the very skilled hands of veterinary surgeon and VetStem proponent, Dr. Jeff Christiansen of Superior Veterinary Surgical Solutions.

We wrote about Dr. Christiansen in a few weeks ago. He is one of VetStem’s most prolific users and has provided this service to over 300 patients. While Raven was anesthetized for her leg repair, Dr. Christiansen collected fat for stem cell therapy. The fat was shipped to the VetStem laboratory where technicians processed it to extract and concentrate the stem and regenerative cells contained therein. Two injectable doses of Raven’s stem cells were prepared and shipped to Dr. Christiansen for treatment and the remaining cells were put into cryostorage for potential future use. Raven received one injection into the fracture repair site and one intravenous injection.

Stem cells have multiple mechanisms of action that can be beneficial when recovering from a major surgery. Stem cells have shown the ability to directly modulate acute pain, down regulate inflammation, and also to reduce the formation of scar tissue. Taken together, stem cells may improve and expedite healing when used in conjunction with surgery.

Since recovery, Raven’s owners stated that you would never know she had a broken leg and that she has “full on Italian Greyhound zoomies with no limp or complaint of pain.” Her owner also stated, “Raven just turned 2 years old and to date has no evidence of pain or difficulty moving around. Between the stem cells and Dr. Christiansen she is as good as new. The VetStem Therapy was highly recommended by the surgeon and for my peace of mind, well worth the money. We now have VetStem keep the stem cells in the event we would ever need them again.”

Raven’s surgically repaired leg

Raven healed after surgery and VetStem Cell Therapy