August 4^th is Assistance Dog Day and next week is International Assistance Dog Week. This is a time to recognize and honor the hard work and selfless love that assistance dogs provide day in and day out. As you probably know, assistance dogs are specially trained to perform specific tasks for people with disabilities. These disabilities can be physical, sensory, psychiatric, intellectual, or mental. There are many types of assistance dogs including guide dogs for the blind, medical and hearing alert dogs, mobility assistance dogs, and more. In this week’s blog, we are going to share a special story about a psychiatric service dog named Max.

Max has been a trained companion for U.S. Army Staff Sergeant Edward Johnson since 2014. Sgt. Johnson, a purple heart recipient, was shot in the head during combat in Iraq in 2006 and was left with a traumatic brain injury. Max helps Sgt. Johnson cope with PTSD and other debilitating ailments related to his injuries.

Unfortunately, Max tore his cruciate ligament in his knee. As a common injury in large breed dogs, cruciate ligament tear is one of the biggest reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs. Additionally, according to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future.

Max was obviously in pain and in need of surgery and other medical procedures. Fortunately, his story made the news and through donations and good will, Max was able to have surgery and treatment with VetStem Cell Therapy. His surgeon, Dr. Jeff Christiansen of Superior Veterinary Surgical Solutions, donated his services and organized donations from several others as well. As an experienced VetStem provider, Dr. Christiansen recommended stem cell and platelet therapy in conjunction with the surgery to aid Max’s healing. VetStem provided a free platelet therapy kit as well as discounted stem cell processing services.

According to Dr. Christiansen, Max recovered completely. But as is common, Max suffered a second cruciate ligament rupture in his other leg just over two years after his first surgery. Once again, Dr. Christiansen and several companies, including VetStem, stepped up to provide this dog with top-notch care. Max received surgery on his other knee in addition to stem cells and platelet therapy. Max once again recovered well and hasn’t required a repeat stem cell treatment since.

While we primarily focus on stem cells, another exciting tool in the regenerative medicine bucket is platelet-rich plasma (PRP). PRP is defined as concentrated platelets in plasma. But what does PRP do and what can it be used to treat?

The Healing Properties of Platelets

To understand how PRP works, we first need to understand what platelets do in the body. Platelets are very small cells found in the blood stream of mammals and are best known for their ability to clot the blood. However, there is much more that these tiny but powerful cells can do. A complex signaling system sent out from damaged cells attracts platelets to an injury and tells them to release several healing molecules that they have stored inside of them. In turn, these healing molecules attract a multitude of additional healing cells (including stem cells) to the site of injury or inflammation. Together, these cells have been shown to reduce pain, remove the damaged cells, build new blood vessels, prevent further tissue damage, and generate new healthy cells in place of the injured ones.

What can PRP be Used to Treat?

In veterinary medicine, PRP is most often used for orthopedic problems such as cruciate ligament tears, osteoarthritis, and tendon injuries in dogs, cats, and horses. However, recent research has shown that PRP can also aid in the healing of skin wounds, corneal (eye) ulcers, surgical incision sites, tooth sockets following extraction, and even muscle tears. Platelet therapy can also be used in conjunction with VetStem Cell Therapy to maximize the effect of both treatments.

PRP Kits: How they Work and the Associated Disadvantages

Historically, PRP has been produced using the patient’s blood. The blood is run through a mechanical device, or kit, each of which requires a unique processing method. The end result is concentrated platelets in plasma (PRP), however the exact concentration of platelets in the final product is not usually known.

This is perhaps the biggest disadvantage when using kits to produce PRP. There are several variables that can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. In a recent comparison of four PRP kits for the production of equine PRP, these kits demonstrated a lack of uniformity relating to the final platelet count and platelet concentration, and each kit failed to meet their respective platelet concentration claim.

Consistency is Key: PrecisePRP™

Fortunately, VetStem found a way to significantly reduce these disadvantages. PrecisePRP™ is a freeze-dried, donor-derived platelet-rich plasma; truly an off-the-shelf PRP. Each vial of PrecisePRP™ is uniform in platelet characteristics and concentration. This eliminates the variability mentioned above so that veterinarians know exactly what they’re injecting every single time, which can increase positive treatment outcomes. Additionally, PrecisePRP™ is not a kit and does not require processing, making it an easy and convenient alternative to currently available PRP kits.

We took the development of this product very seriously to ensure a positive safety profile. All donors are screened according to the FDA CVM guidance 254. Each batch is sterility, endotoxin, and quality tested to meet precise product release specifications. In controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™. This unique product is currently available in both dog and horse formats.

Pretty exciting stuff! Want to learn more? Visit www.vetstem.com/pprp.php for more information.

A sad story that we hear a lot is when a ball-loving dog is no longer able to play fetch due to arthritis or some other orthopedic injury. That was the case for Sherlock, a nearly 100-pound Staffordshire terrier/rottweiler mix. Though Sherlock loved to chase his ball, as he got older, his body started slowing down and he was diagnosed with arthritis in all four limbs. In an effort to not take away his favorite activity, his owners continued to play ball with a little less intensity. And then he tore his cruciate ligament in his right knee.

Fortunately for Sherlock, his veterinarian recommended using VetStem Cell Therapy in conjunction with surgery. Stem cells have the ability to reduce pain, inflammation, and minimize the formation of scar tissue. In addition to his injured knee, Sherlock’s veterinarian treated both of his elbows and his non-injured knee to give him some relief from the arthritis in those joints.

Sherlock’s owner reported that he responded well to his initial stem cell treatment but that shortly after, he injured the cruciate ligament in his left knee. Unfortunately, this is more common than you may think. According to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future. This time, Sherlock’s veterinarian was able to request doses from his stored stem cells, which she administered during the surgery on his left knee. Sherlock once again received an injection of his own stem cells into each knee and each elbow.

After treatment, his owner said that his recovery went from six weeks to three-and-a-half weeks. She stated, “He healed so quickly that it surprised everyone. He was 12 years old by this time and a full recovery seemed almost too hopeful to wish for, but instead we not only got a full recovery but a faster recovery than before.” She went on to state, “Sherlock is now 13 years old and we do not run and chase balls anymore, but we enjoy walks on the beach and lots of snuggles and I am so grateful that he is still here feeling good and enjoying life with me. Stem cell therapy made an immense difference in his ability to live a high quality life in his older years.”

Does your dog suffer from osteoarthritis or have they injured their cruciate ligament? If so, VetStem Cell Therapy may help. Speak to your veterinarian or contact us to receive a list of VetStem providers near you.

VetStem founder and CEO, Dr. Bob Harman, recently joined Fuzzybutts and Friends on a podcast to discuss VetStem Cell Therapy and the science of stem cells. Joining him is Dr. Angie Zinkus, veterinarian and VetStem enthusiast at Germantown Parkway Animal Hospital. This podcast really gets down to the nitty gritty about stem cells and the various diseases that have been treated with VetStem Cell Therapy. Some of the big questions that are addressed are:

What are stem cells? Where do they come from? What are the mechanisms of action/how do they work? What CAN’T be treated with stem cells? And more!! You don’t want to miss this one!

Click the image below to check out the podcast:

All of us have heard the term “stem cells” and most of us have some basic understanding of what that means. Stem cells are often referred to as the building blocks of life. Thus, when it comes to stem cells, many people think of embryonic stem cells. But when we talk about VetStem Cell Therapy, we’re actually talking about adult stem cells.

Adult Stem Cells vs. Embryonic Stem Cells

There are several differences between embryonic and adult stem cells. Embryonic stem cells serve one purpose: to form whole organs and organisms. They are truly the “building blocks of life.” Embryonic stem cells exist only at the earliest stages of development, and they are pluripotent, meaning they can differentiate into any cell type.

Adult stem cells on the other hand include multiple types of stem cells that are present in almost all tissues of the adult body. They can be multipotent or unipotent, meaning they can only differentiate into one type of cell. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that have demonstrated the ability to differentiate into multiple cell types including tendon, ligament, bone, cartilage, cardiac, nerve, muscle, blood vessels, fat, and liver tissue.

Adult Stem Cells Mechanisms of Action

Adult stem cells are utilized by the body to replenish dying cells and to repair damaged tissues. This discovery led to multiple studies to help determine the full therapeutic benefits of adult stem cells. VetStem uses adult MSCs in an effort to repair damaged tissues in animals with various injuries and diseases. But this is not the only mechanism of action that stem cells utilize in the healing process. Stem cells have also been shown to down-regulate inflammation, reduce pain, and modulate the immune system. All of these mechanisms, and more that we’re still learning about, make stem cell therapy a multimodal approach to healing.

Ideal Source of Adult Stem Cells

When used for VetStem Cell Therapy, adult MSCs are extracted from fat tissue, one of the richest sources of MSCs in the body. Fat tissue is also relatively easy to collect during a simple anesthetic procedure similar to a spay. Most animals recover quickly and uneventfully from the procedure, compared to more painful and invasive stem cell collection techniques. Additionally, fat is generally abundant in the body, even in skinny animals, making it an ideal source of stem cells.

If you think your pet may benefit from VetStem Cell Therapy, contact us to receive a list of providers in your area.  

Today is Take Your Dog to Work Day and VetStem is no stranger to having our furry, four-legged companions in the office! On any given day, there may be a handful of dogs lounging around the office, offering tail wags, and eagerly requesting ear scratches from passers-by. And we wouldn’t have it any other way!

We of course love the extra puppy snuggles, but there are additional benefits to bringing your dog to work. According to one study, there is a potential correlation between bringing your dog to work and a reduction in stress levels. Scientists found that people who took their dogs to work reported lower stress throughout the day than employees without pets or those who had pets but didn’t take them to work.

Another study found that 90 percent of employees in pet friendly workplaces feel highly connected to their company’s mission, fully engaged with their work, and willing to recommend their employer to others. Additionally, more than three times as many employees at pet friendly workplaces report a positive working relationship with their boss and co-workers and are more likely to stay with a company long term. And the benefits don’t end there! Check out more details of the study here.

We feel super fortunate to work in a pet friendly office, especially since we are in the veterinary field and are all passionate animal lovers! Here are just a few pictures of our dogs hanging around the VetStem office.

As you probably know, much of the VetStem blog is spent discussing the treatment of arthritis with stem cells. We talk about things like joint dysplasia and cruciate ligament tears as catalysts for the development of arthritis. In today’s blog, we are discussing Fragmented Coronoid Process, or FCP, a developmental defect that causes arthritis in the elbows.

Nikolai Augustus, a Labrador retriever, was 2 years old when he began limping. X-rays revealed he had broken bone fragments in both of his elbows as a result of fragmented coronoid process, or FCP. FCP is one of the main diseases associated with elbow dysplasia. It is a developmental defect of the two small bony protrusions on the end of the ulna, known as the coronoid processes, within the elbow joint. In this condition, one of the bony protrusions develops a fissure or crack and separates from the ulna. FCP may result in instability and pain as well as decreased mobility and swelling.

The treatment of choice for FCP is surgical removal of the bone fragments and any abnormal cartilage. This procedure can be performed arthroscopically by an orthopedic surgeon, which results in a smaller incision and less damage to the supporting elbow structures. In all cases however, regardless of surgical repair, the patient will develop some degree of arthritis. That’s where VetStem comes in!

Niko’s veterinarian recommended arthroscopy in addition to treatment with VetStem Cell Therapy. Stem cells are regenerative cells that can differentiate into many tissue types and have demonstrated the ability to reduce pain and inflammation, help to restore range of motion, and stimulate regeneration of tendon, ligament, and joint tissues. By using VetStem Cell Therapy in conjunction with surgery, Niko’s vet hoped to delay the progression and reduce the severity of degenerative joint disease in his elbows.

To begin the process, Niko’s vet collected fat tissue from his abdomen in a minimally invasive anesthetic procedure. The fat was aseptically packaged and shipped to the VetStem processing laboratory in Poway, California. Lab technicians processed the fat to extract and concentrate the stem and regenerative cells contained therein. The cells were divided into doses, and two injectable doses were shipped to Niko’s vet for treatment. Approximately 48 hours after the initial fat collection procedure, Niko received one dose of his own stem cells into each elbow.

According to Niko’s owner, he had a great response to the treatment. His owner stated, “One year after surgery and stem cell therapy and Niko is running and playing with the energy of a 3-year-old. We are thankful our vet recommended stem cell therapy for Niko and that he has the bank of stem cells to help treat Niko in the future.”

In addition to the two stem cell doses that were shipped for immediate treatment, several doses of Niko’s stem cells were put into cryopreservation. This is particularly valuable for a patient like Niko who will never have perfect, arthritis-free elbows. In fact, approximately 15 months after his initial treatment, Niko received a follow up treatment identical to his first using some of his banked stem cell doses. Niko’s additional cells will remain in cryopreservation and can be accessed for treatment as needed for the remainder of his life.

If you think your pet may benefit from treatment with VetStem Cell Therapy, contact us to receive a list of providers in your area.

As Pet Appreciation Week wraps up, we just wanted to share appreciation for some of the VetStem pack! These critters bring us so much joy and so many laughs!

Thank you Mick for being a great hiking/camping buddy!

Thank you Scarf for the constant laughs.

Thank you Willow for being so loyal.

Thank you Streaker for the best cuddles.

Thank you Darby for providing constant entertainment!

Thank you Ali’i for the best snuggles.

Thank you Wesley for constantly making us laugh.

Thank you Udon for being a yes noodle instead of a nope rope!

Yesterday, June 1^st, was International Sheltie Day. To celebrate, we have a blog for you all about Lady, a Sheltie who received VetStem Cell Therapy for arthritis and a cruciate ligament tear.

Lady suffered with arthritis since she was two years old for which she received various medications at different times. When she was eight years old, she tore the cruciate ligament in her left knee. Though her injury required surgical repair, her veterinarian, Dr. Jeff Christiansen of Superior Veterinary Surgical Solutions, recommended treatment with VetStem Cell Therapy in addition to surgery.

During her knee surgery, Dr. Christiansen collected a sample of fat tissue from her abdomen. The tissue was sent to the VetStem laboratory where it was processed to extract and concentrate the stem and regenerative cells contained therein. Five stem cells doses were prepared and shipped to Dr. Christiansen while the rest of Lady’s stem cells were put into cryopreservation for future use.

In addition to her injured knee, Dr. Christiansen planned to treat Lady’s arthritic joints. Approximately 48 hours after her surgery, Lady received a dose of her own stem cells into her left knee, left hip, and both carpi (wrists), as well as an intravenous dose.

Lady’s owner was very happy with the results of her treatment with VetStem Cell Therapy. She stated, “Prior to the stem cell treatments, Lady had a hard time going from a sit-to-stand position and would go outside for no more than 10 minutes at a time. Now she goes on 30-50 minute walks. She is far more playful than she was before the stem cell treatment. The stem cell treatment has been life changing for my fur baby. I would highly recommend stem cell therapy!”

Lady’s initial treatment was back in 2015. In the following years, she received additional treatments utilizing her stored stem cells to help her maintain a good quality of life. She initially received one intravenous dose roughly every 9-13 months. Approximately two years after her last intravenous dose, she received a round of joint injections in addition to an intravenous dose.

This treatment schedule is not uncommon for a dog with arthritis. Because arthritis is a degenerative disease, stem cells can slow the progression of the disease but ultimately will not cure the condition. This is important to note because many pets will require repeat or routine treatments as they continue to age. Fortunately, VetStem has the ability to both store stem cells and produce more stem cells, should your pet require them in the future. This means that just one fat collection can provide a lifetime supply of stem cells for your pet. Stem cells have been shown to reduce inflammation and pain and to contribute to the regeneration of damaged tissues such as cartilage and tendon/ligament. Interested in VetStem Cell Therapy for your pet? Speak to your veterinarian or contact us to receive a list of VetStem providers near you.

All month long we’ve been discussing arthritis in honor of Arthritis Awareness Month. We’ve covered arthritis in cats and dogs as well as using exercise to manage your pet’s arthritis. Another tool to help reduce symptoms of arthritis and actually help to repair damaged cartilage tissue is VetStem Cell Therapy. This week, to wrap up our month of Arthritis Awareness blogs, we are sharing Gracie’s stem cell success story.

Gracie, a spirited Golden Retriever, was two years old when she suddenly could not stand up. Prior to this, her personality had changed as well. She went from being a rambunctious, active pup to very calm. It turns out, she was struggling with pain. Her owners immediately took her to the veterinarian where it was determined she has a bad case of bilateral hip dysplasia resulting in osteoarthritis. Hip dysplasia is a deformity of the ball and socket hip joint that occurs during growth. The deformity results in joint laxity (looseness) and eventually leads to osteoarthritis (OA). OA is a painful condition that can greatly reduce a dog’s quality of life.

Fortunately for Gracie, her veterinarian works with VetStem proponent Dr. Angie Zinkus at Germantown Parkway Animal Hospital. Dr. Zinkus has treated multiple arthritic patients with VetStem Cell Therapy and agreed Gracie was a good candidate for the procedure. In this particular case, Dr. Zinkus mentored Dr. Susannah Mays to familiarize her with the VetStem process.

First, Dr. Mays collected fat tissue from Gracie’s abdomen during a minimally invasive anesthetic procedure. The fat was aseptically packaged and shipped to the VetStem processing laboratory in Poway, California. Lab technicians processed the fat to extract and concentrate the stem and regenerative cells contained therein.

Gracie’s cells were divided into doses and a total of nine stem cell injections were shipped to her veterinarian for treatment while the rest were put into cryostorage. Approximately 48 hours after the initial fat collection procedure, Gracie received injections of her own stem cells in her hips, knees, elbows, shoulders, as well as an intravenous injection. According to Dr. Zinkus, though Gracie’s knees, elbows, and shoulders did not show signs of arthritis, she prefers to treat each joint as a preventative measure to help protect against the development of future osteoarthritis.

In addition to stem cell therapy, Gracie received platelet rich plasma (PRP) injections into her joints. PRP and stem cell therapy work synergistically. Concentrated platelets accelerate internal healing processes by attracting stem cells, supporting an anti-inflammatory environment, and stimulating local tissue repair processes.

According to Gracie’s owner, the stem cell and PRP treatment was a huge success! Her owner noted that it only took a few months before they noticed a vast improvement stating, “Gracie is back to her silly self, running as fast as she can to chase our backyard squirrels!! Thank you, VetStem and Dr. Zinkus for this wonderful solution to Gracie’s painful hips.”

Gracie’s story is just one of many that we have received from pet parents. As we discussed in a recent blog, Osteoarthritis is one of the most common diseases in dogs and pain associated with osteoarthritis can greatly reduce a dog’s quality of life. But VetStem Cell Therapy can help! According to surveys answered by owners and veterinarians, greater than 80% of dogs showed an improved quality of life after receiving VetStem Cell Therapy for osteoarthritis.

Curious if your dog may benefit from treatment with VetStem Cell Therapy? Speak to your veterinarian or contact us to receive a list of VetStem providers near you.