VetStem founder and CEO, Dr. Bob Harman, recently joined Fuzzybutts and Friends on a podcast to discuss VetStem Cell Therapy and the science of stem cells. Joining him is Dr. Angie Zinkus, veterinarian and VetStem enthusiast at Germantown Parkway Animal Hospital. This podcast really gets down to the nitty gritty about stem cells and the various diseases that have been treated with VetStem Cell Therapy. Some of the big questions that are addressed are:

What are stem cells? Where do they come from? What are the mechanisms of action/how do they work? What CAN’T be treated with stem cells? And more!! You don’t want to miss this one!

Click the image below to check out the podcast:

In last week’s VetStem blog, we introduced you to veterinarian and stem cell therapy proponent, Dr. John Hutchens. Dr. Hutchens shared his thoughts and experiences regarding the use of VetStem Cell Therapy in his patients. Check it out if you haven’t already, it’s a good one with lots of great information.

This week, we are sharing the experience of one of Dr. Hutchens’ VetStem patients, Holly. Holly is a chocolate Lab that received VetStem Cell Therapy for osteoarthritis in her hips and knees. Her owners kept a near daily journal of her treatment and initial progress. It’s rare that we get such a glimpse into the stem cell recovery process, so we wanted to share this with you! Check it out below.

Tuesday, July 25, 2022

Holly, our 11-year-old Labrador Retriever, had surgery today to remove a small amount of adipose tissue (fat) from her abdomen. It was sent to VetStem in California and should arrive there tomorrow. VetStem will isolate the stem cells and prepare 5 shots for Holly, one for each hip and one for each knee, and one IV. The rest will be stored by cryopreservation for future use. Stem cells are used for regenerative purposes in dogs, cats, and horses. VetStem will send the shots and IV back to my vet on Thursday for injection Friday morning if all goes well.

Friday, July 28

When we arrived at the vet at 8:00 am, we were told the shipment had been delayed in Indiana and was not there yet. My vet, Dr. Hutchens, had already talked to VetStem and they assured him it would be here first thing this morning. Since the cells are viable for 48 hours after shipping, if we had to, we could wait and do the procedure Saturday morning. He was willing to come in on a Saturday if they didn’t show up this morning. He is awesome. This was a minor blessing because Holly had developed diarrhea Wednesday evening and it gave the vet time to give her some meds to settle her stomach and start an IV to hydrate her. We left Holly at the vet and prayed the shipment would arrive soon.

Around lunch time we got a call from the vet. The shipment had arrived right away. Holly had already gotten her injections and IV and we could pick her up at 4:30. She was bright, perky, and ready to go home. She had a lot of swelling from the injections, and she was very sore on her back legs. She looked like a checkerboard where her hair had been clipped for her surgery and from her shots. She woke up twice that night and had to be helped up so she could go out to relieve herself.

Saturday, July 30

Her legs are still very sore. She is having difficulty getting up off the floor. We don’t have carpet and she slips when trying to get up. I’ve had to lift her up several times when she needed to get up. She slept all night.

Sunday, July 31

Holly is getting up easier today. In the morning she was stiff and had a hard time getting up but this afternoon she is getting up on her own and walking more.

Monday, August 1

Holly is so much better today. She can get up on her own and trots down the hall, instead of walking! She goes up and down her outside ramp with ease. This afternoon I rolled her ball about 10 feet and she actually ran after it. She is as good as, and maybe slightly better than she was before all this.

Tuesday, August 2

Wow, Holly went for a walk around the back pasture with Don (husband). Normally, she would go halfway around the acre, and stop while he finished his walk. Today, she walked around it 5 times! She hasn’t done that in about a year. I’ve cut back on her pain meds. Before all this, she was on 1.5 Rimadyl tablets and 2 Gabapentin capsules every day. She is only on 1 Rimadyl tablet and 1 Gabapentin a day now.

Wednesday, August 3 and Thursday, August 4

Holly continues to improve. It’s been a while since she would sit up and now, she is sitting again instead of lying on the floor all day. Unfortunately, that means she is begging for food. LOL. She has more energy, less pain, and is much happier. Her quality of life is so much better now.

Friday, August 5

We took her back to the vet to have her stitches out. The vet was amazed at how much better she was. She went from not being able to get up on her own, to getting up by herself, trotting down the halls. She is going up and down her ramp with ease, sitting up and being happy again! I recommend stem cell therapy to anyone who has a dog, cat, or horse that has health problems that this could fix. It’s a regenerative medical therapy that will enable the body to repair, replace, restore, and regenerate damaged or diseased tissues using its own cells.

Monday, August 8

Today Holly ran from the living room to the side door and barked when Robin came over and rang the doorbell. She commented that Holly had not done that in quite some time. This is so awesome.

Friday, August 12

Holly ran about 3 feet today. We threw (rolled) a ball about 5 feet and she ran after it. It didn’t last long but she actually ran a little.

August 16 & 18. This is week 3.

This is amazing. Robin threw Holly’s ball about 50 feet. Holly took off running as fast as she could (not very fast), trying to catch it. It’s crazy how much she has improved! She tried going down the deck stairs but fell at the bottom. She is still not quite strong enough to use the stairs going down all the time. She still mostly uses the ramp. We changed her meds to 1.5 Rimadyl only. We think the Gabapentin was causing her diarrhea.

August 24 & 25

Holly woke up wanting to play! She playfully growled and barked and tried to grab Don’s hand while squirming around in her bed and wagging her tail. She loves playing with him and never bites. LOL. When we opened the gate to the front pasture, she ran about 50 feet to meet Abby, Robin’s dog. They bounced around for a minute, then each went their own way sniffing everything they could find. She is actually interested in being outside now instead of lying around in the house all day. The next morning, she was stalking squirrels. She ran half the yard’s length then slowed down to a walk when the squirrel climbed a tree. She found one of her beloved balls and carried it around with her for half an hour before going back in the house. I can’t believe how much energy she has now.

September – Week 1

Holly has started using our deck stairs to go down to the yard again! Before, she would use her ramp which has roofing shingles tacked on it so she wouldn’t slip. Now, she is strong enough that she doesn’t fall at the bottom step anymore. She still uses the ramp to get back up to the deck.

September – Week 2 (approx. 45 days after treatment with stem cells)

Holly ran all the way across our back yard this week. That’s about 100 feet! I also noticed that she has started jumping up and down a little when she gets really excited or someone comes to the house. These stem cells seem to still be working. I wonder what it could do for me. LOL. It’s like the Fountain of Youth!

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As you can see, VetStem Cell Therapy helped Holly live a better quality of life. At 11 years old with osteoarthritis in multiple joints, the treatment didn’t make her like a puppy again. But it did help her get moving so she could get back to some of her favorite things in life like playing with her ball, walking with dad, stalking squirrels, and greeting visitors. If you think your dog may benefit from treatment with VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers near you.

We have a special veterinarian highlight this week. This will actually be a two-part blog series in which we will learn about Dr. John Hutchens of Westmoreland and Slappey Animal Hospital this week and his patient, Holly, next week.

According to his bio on the hospital website, Dr. John Hutchens received his Bachelor of Science degree in Animal Science from the University of Georgia and his Doctorate of Veterinary Medicine from the University of Georgia, College of Veterinary Medicine. He has been utilizing VetStem Cell Therapy since 2013. We recently caught up with Dr. Hutchens to ask him some questions about his use of stem cells.

Why do you find VetStem Cell Therapy to be a valuable addition to your practice?

VetStem Cell Therapy adds value to my practice by significantly improving my patient’s quality of life. Each of my patients have a special relationship with their human counterparts. That relationship can be greatly impacted by the pain associated with degenerative joint disease, arthritis, or injury. VetStem Cell Therapy helps to restore my patient’s ability to move comfortably, restoring their ability to enjoy life and interact with the family they love. There is HUGE value in providing relief of pain and suffering. You cannot put a monetary value on improving a pet’s quality of life and the relationship they have with their family. PRICELESS. 

What injuries/ailments do you typically treat with VetStem Cell Therapy?

I have used VetStem Cell Therapy to treat dogs with hip dysplasia and chronic arthritis of the knees and hips. I have treated the average family pet that couldn’t get up the stairs due to severe hip pain. I have also treated the working dog that was diagnosed with hip dysplasia whose human was told by a veterinarian he would no longer be able to do the job he loved. Guess what, after stem cell therapy he continued doing what he loved to do with comfort.

Please describe your ideal stem cell patient- what criteria must they meet in order to recommend stem cell therapy?

My ideal stem cell patient is a dog whose mind is ready and willing to go, but their joints tell them “NO”. This is a patient that wants to interact with the world around them, but because of pain, they just lie around watching the world go by. These are the patients that wag their tail when you walk in the door, but don’t get up because it just hurts too bad to move.

The things I want to know before deciding if a patient is a good candidate for stem cell therapy:

#1 Does the patient have cancer or a history of cancer?

#2 What therapeutics have they tried prior to stem cell therapy and what were the results?

#3 Are the clients willing to bring the patient back for follow up visits to assess progress?

What advice can you offer pet owners considering stem cell therapy for their pet?

Stem cell therapy sounds too good to be true, but in reality, it works! Stem cell therapy is safe, it’s effective, and it’s life changing. With stem cell therapy, you are utilizing your dog’s own naturally occurring healing properties, stem cells, to provide relief from joint pain. It’s not magic, it’s biology and amazing medical advancement.

We hear your patient, Holly, had a great response to treatment with VetStem Cell Therapy. Can you tell us a bit about her treatment and outcome?

I’ve seen Holly many times over the years and watched as her body began to suffer from the impact of degenerative joint disease. She is one of the absolute sweetest patients I see, but because of joint pain, Holly could not comfortably get up to greet me when I walked into the room. Holly had previously been prescribed Rimadyl, Gabapentin, and Adequan at different times to treat her pain and inflammation with mixed results. Ultimately, the discomfort seemed to overwhelm the therapeutics. During one of Holly’s appointments, I discussed the success I had with other patients, similar to Holly, that had experienced dramatic improvement using stem cell therapy. It didn’t take much to convince the Cooks that Holly needed stem cell therapy.

The VetStem Process

We obtained the fat necessary to harvest Holly’s stem cells from a small incision in her abdomen. Holly did fantastic through the collection procedure! The collected fat was then shipped overnight to VetStem for processing. Within 48 hours I was holding the healing power of Holly’s stem cells in my hands! AMAZING!

Holly was brought back into the office to receive her stem cell therapy two days after the collection procedure. Holly’s stem cells were injected in both of her hips, both knees, and given to her intravenously. She was sent home the same day for monitoring and recovery.

Holly returned seven days later to have the sutures from her abdominal incision removed. The response to treatment was AMAZING. I knew that stem cell therapy was effective, but what I saw that day was miraculous. Holly, the dog that could barely get up without help, was bouncing around the exam room like a brand new dog. I watched as a previously lame dog walked without assistance. Seeing her improvement brought tears to my eyes and a HUGE smile to my face.  I would say Holly is a tremendous stem cell success story.

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We would like to thank Dr. Hutchens for taking the time out of his very busy schedule to answer all of our questions. Hopefully his answers help you to make informed decisions about potentially treating your pet with stem cell therapy. Or, if you are in the Perry, GA area and are curious about VetStem Cell Therapy for your pet, Dr. Hutchens is a great resource. Also, follow him on Instagram @johnhutchensdvm for super cute and educational veterinary content!

It’s still Animal Pain Awareness Month so we have another pain-themed blog for you. This week, we are talking about how stem cell therapy may reduce pain in pets. We frequently share stories about pets who have gained a better quality of life after treatment with VetStem Cell Therapy. And while we know stem cells have multiple mechanisms of action, one lesser-known mechanism is the ability to modulate pain.

You may remember last week’s blog in which we discussed the various classifications of pain. To briefly review, those were:

• Nociceptive – caused by noxious stimulation (injury/physical damage, exposure to chemicals or exposure to extreme temperatures)
• Inflammatory – caused by acute or chronic inflammation
• Neuropathic – from damage to an element of the nervous system

Below, we will discuss how stem cells have the ability to address each one of these pain classifications.

Stem Cells are Anti-Inflammatory

For many years, differentiation was believed to be the primary function of regenerative stem cells. More recent literature, however, supports the notion that stem cell therapy may be an effective treatment option for pain management. The ability of stem cells to regulate inflammation is important when it comes to pain management. By reducing inflammation, stem cells promote healing and increased comfort.

Stem Cells Act Directly on Acute and Chronic Pain

While a reduction in inflammation can lead to increased comfort, current literature supports that stem cells have the ability to address both acute and chronic pain directly. Stem cells have been shown to secrete pain blocking cytokines (small proteins), which can have opioid-like effects. Stem cells have also shown the ability to reduce neuroinflammation (inflammation of the nervous tissue).

If you think your pet may benefit from stem cell therapy, contact us for a list of VetStem providers in your area.

November is National Senior Pet Month, and we want to show those frosted-faces some extra special attention in this week’s blog! Like people, increased age is a risk factor associated with osteoarthritis. One study conducted in the UK indicated that dogs over eight years old were most frequently diagnosed with osteoarthritis. The same study found that dogs over twelve years had the greatest odds of being diagnosed with osteoarthritis compared to other age groups. These findings support the notion that osteoarthritis is predominantly a disease of aging.

Osteoarthritis is the Number 2 Reason for Euthanasia

Given that approximately 1 in 5 dogs in the United States are affected by osteoarthritis, it comes as no surprise that the disease has previously been labeled as the second most common reason for euthanasia. Though there are several treatment options available to help alleviate the symptoms of arthritis, many of them come along with unpleasant side effects and/or begin to lose efficacy after prolonged use.

VetStem Cell Therapy for Osteoarthritis

While it is not a cure for osteoarthritis, as there is no cure for this progressive disease, many arthritic pets have benefited from treatment with VetStem Cell Therapy. Based on information obtained from veterinarians and dog owners, 81% of arthritic older dogs who were treated with VetStem Cell Therapy experienced an improved quality of life. In addition, 63% were not re-treated in the first year, meaning the benefits of stem cell therapy lasted longer than a year. Below are some additional numbers regarding older dogs who received VetStem Cell Therapy for osteoarthritis.

Is VetStem Cell Therapy Right for your Senior Pet?

Though stem cell therapy may lead to a better quality of life in some pets, it may not be the best option for your pet if they do not tolerate anesthesia well or if they have active cancer, which is more prevalent in older pets and is contraindicated with VetStem Cell Therapy. Thus, if you think your pet may benefit from treatment with stem cells, the first place to start is talking with your veterinarian. He/She can perform a comprehensive exam to determine if your pet may be a good candidate for stem cell therapy.

Need to find a vet who provides VetStem Cell Therapy? Click here.

One topic we have not covered is wound healing. Chronic wounds can be a major problem for pets and present many challenges for veterinarians. Some wounds require significant ongoing medical care which can be both stressful and expensive for pet owners.

Stem Cell Therapy for Wound Healing

Stem cells have many potential uses. Veterinarians primarily use VetStem Cell Therapy to treat orthopedic conditions as well as some internal medicine conditions. Stem cells have shown the ability to reduce inflammation and pain and to lead to tissue regeneration. Adipose-derived stem cells can differentiate into multiple tissue types, including skin. Stem cells also release growth factors and cytokines, which the body uses to promote healing.

There is a growing body of evidence demonstrating the potential efficacy of stem cell therapy for wound healing. That being said, there is still significant research to be done before any claims of definitive treatment can be made. While the research continues, some veterinarians (and human physicians) are using stem cell therapy experimentally to help with wound healing.

Jaguar Receives Stem Cell Therapy for Severe Burns

In September, a story came out about a jaguar who was severely burned in a wildfire in Brazil. Amanaci, whose name means “goddess of the waters”, was found in an abandoned hen house amidst the fires in the Pantanal wetlands. She had third-degree burns on all four paws and on her belly. Her mammary glands were swollen with milk, indicating she recently had cubs. Veterinarians speculated that Amanaci spent considerable time trying to protect and save her cubs, which is why she was burned so badly. Unfortunately, no cubs were found.

Amanaci was transported to the NEX Institute where veterinarian, Daniela Gianni and several others took over her care. Dr. Gianni, who has previous experience using stem cell therapy in large cats, treated Amanaci’s wounds with multiple rounds of stem cell treatments along with other therapies due to the severity of her condition. And though her treatment is progressing well, it is believed she is not capable of surviving in the wild at this point. Amanaci will likely continue living at the institute along with 23 other jaguars. To read more about Amanaci’s story, click here. Or click here to watch a brief video.

As Animal Pain Awareness Month continues, we wanted to share some information about how stem cells may relieve pain in pets. We frequently share stories about dogs with osteoarthritis who regain mobility and a better quality of life after receiving VetStem Cell Therapy. While stem cells utilize multiple mechanisms of action, one primary benefit of stem cells is their ability to reduce inflammation and pain.

Pain in Pets

As we mentioned in last week’s blog, pets can suffer from acute and chronic pain. Pain in pets can result from a variety of causes and there are three primary classifications of pain:

• Nociceptive – caused by noxious stimulation (injury/physical damage, exposure to chemicals or exposure to extreme temperatures)
• Inflammatory – caused by acute or chronic inflammation
• Neuropathic – from damage to an element of the nervous system

Stem Cells are Anti-Inflammatory

One major mechanism of action is the ability of stem cells to down regulate inflammation. By reducing inflammation, stem cells promote healing and increase comfort. When used to treat osteoarthritis, stem cells may promote cartilage regrowth and therefore healthier and less painful joints.

Stem Cells Act Directly on Pain

While a reduction in inflammation can lead to increased comfort, current literature supports that stem cells have the ability to address both acute and chronic pain directly. Recently, there have been studies to evaluate stem cells’ direct effects on modulating pain. Stem cells have been shown to secrete pain blocking cytokines (small proteins), which can have opioid-like effects. Stem cells have also shown the ability to reduce neuroinflammation (inflammation of the nervous tissue).

If you think your pet may benefit from stem cell therapy, contact us for a list of VetStem providers in your area.

As the first company to provide adipose derived stem cell services to veterinarians in the United States and Canada, VetStem has processed nearly 14,000 patient samples resulting in over 30,000 stem cell treatments for animals. VetStem Cell Therapy is primarily used for the treatment of orthopedic conditions such as osteoarthritis as well as torn tendons and ligaments in dogs, cats, and horses. In addition to domestic animals, VetStem has worked with multiple exotic animal organizations to provide stem cell therapy for several exotic species. (Read last week’s blog about Brody the bear!)

Veterinarians have also used VetStem Cell Therapy to treat several “non-standard” indications. Some of these include feline chronic kidney disease, inflammatory bowel disease, feline gingivostomatitis, and canine keratoconjunctivitis sicca (“dry eye). While we are still researching the full capabilities of stem cells, veterinarians have seen promising results when treating these and other conditions with VetStem Cell Therapy.

VetStem has been providing stem cell processing services to veterinarians for their patients for over 17 years. We pride ourselves on providing the highest quality stem cell processing services for all patient samples. Our laboratory technicians undergo extensive training and dedicate the majority of their workday to stem cell processing. All patient samples are processed in bio-safety cabinets in hepa-filtered cleanrooms. We take sterility and patient safety very seriously.

In addition, VetStem determines the cell yield and viability of each sample to ensure an accurate dose prior to shipment. Using cell counting technology allows us to know the number of cells packaged in each stem cell injection. We continually draw upon existing and new research as well as 17+ years of experience to determine appropriate cell numbers.

If you think your pet may benefit from stem cell therapy, speak to your veterinarian about the possibility of using VetStem Cell Therapy. We have provided a letter you can take to your vet to help them get better acquainted with the science behind stem cell therapy and VetStem’s services. Or you can contact us to receive a list of VetStem providers in your area.  

The American College of Regenerative Medicine (ACRM) has asked VetStem CEO, Dr. Bob Harman, to join their board of directors. As the CEO and co-founder of both VetStem and human subsidiary, Personalized Stem Cells, Inc. (PSC), Dr. Harman has nearly two decades of experience working with stem cells and regenerative medicine.

The first of its kind, the ACRM is a multi-specialty, interdisciplinary medical organization. The ACRM was formed to promote the science and ethical use of regenerative medicine with a strong emphasis on global interdisciplinary collaboration. Board members include medical doctors and surgeons, a dentist, a registered nurse and our very own veterinarian, Dr. Harman.

The ACRM’s mission statement encompasses everything from physician and patient education to safety and scientific advancement. While regenerative medicine and stem cell therapy is not new, there is still much to learn about regenerative cell therapies. The ACRM is fully committed to patient safety and a high standard of care. Like VetStem and PSC, the ACRM advocates for patient safety by following FDA guidelines and maintaining compliance.

The interdisciplinary focus of the ACRM will allow for the amalgamation of knowledge and expertise from doctors across multiple fields. Dr. Harman brings nearly two decades of experience with regenerative medicine in the veterinary field to share. With the launch of PSC in 2018, Dr. Harman can also provide insight into human regenerative medicine and FDA approved stem cell clinical trials. We hope this “One Medicine” approach will ultimately lead to understanding regenerative cell therapies more fully and open the door for additional FDA approved regenerative treatment options.

Our human stem cell company, Personalized Stem Cells, Inc. (PSC), recently announced that they filed a request with the FDA for expedited review of an Investigational New Drug (IND) application for the treatment of COVID-19 patients with stem cells. PSC was asked by the White House Coronavirus Task Force to apply for expedited review through a new FDA program called the Coronavirus Therapeutic Accelerator Program (CTAP). CTAP was launched to help expedite the approval process of clinical trials for promising COVID-19 therapies.

Stem Cells for COVID-19

Recent studies evaluating the effects of stem cell therapy in COVID-19 patients have come out of China and Israel showing strikingly positive results. Stem cells have anti-inflammatory properties and the ability to reduce scar tissue formation. Stem cell therapy has the potential to reduce the serious lung complications that occur as a result of infection with COVID-19. The goal of treatment is to reduce time spent in the ICU, reduce ventilator needs, and increase chances of survival for seriously ill COVID-19 patients.

PSC has scaled up production of stem cells in their FDA-inspected facilities to be ready to provide stem cell treatments upon FDA approval. If approved, the initial COVID-19 clinical trial, termed “CoronaStem 1,” will provide treatment for twenty hospitalized COVID-19 patients with serious complications. The first trial will be conducted in a limited number of local San Diego hospitals. PSC anticipates additional approvals and potential compassionate use in the future to allow for many more patients to be treated.

How can you help?

As a small business, PSC is utilizing their own resources to ramp up stem cell production. However, supplies and laboratory technicians are necessary to further increase production of stem cells. PSC plans to provide stem cell treatments to COVID-19 patients at no cost to the patient which requires additional money to pay the doctors, nurses and other healthcare workers who will be performing the clinical trial. Thus, PSC is reaching out to the public for donations to help in this fight against COVID-19. Your tax-deductible donation will allow PSC to provide stem cell treatments for as many COVID-19 patients as possible. All donations will go towards increasing stem cell production and paying doctors, nurses, technicians, and all those involved in performing the medical procedures for the clinical trial.

While the COVID-19 pandemic has impacted us all, many of us are looking for ways in which we can help. PSC has partnered with the San Diego Foundation, a 501c3 organization, to collect tax-deductible donations to further PSC’s efforts. Learn more about how your donation can help PSC fight COVID-19.

You can make a difference! Click here to donate today.