Over 7,000 horses have had their fat tissue processed at VetStem. Like dogs, horses primarily receive VetStem Cell Therapy for orthopedic conditions such as injured tendons, ligaments, and joints. One common condition in sport horses is an injured suspensory ligament.

What is the suspensory ligament and how is it injured?

The suspensory ligament supports a horse’s fetlock joint in all four limbs. While the ligament is strong, it is only slightly elastic. Stress on the ligament can lead to injury and may occur from various activities such as running fast or landing a jump. The injury can be chronic in nature, where repetitive stress leads to tearing of fibers. In an acute injury, numerous fibers can rupture all at once.

What are the symptoms of an injured suspensory ligament?

Symptoms of an injured suspensory ligament vary depending on the location and severity of the injury. Some horses will show only subtle or inconsistent lameness while others may show no obvious lameness. However,  the horse’s performance will often suffer. For those horses with more obvious lameness, symptoms may worsen with exercise and improve with rest. With injury to the branches, the affected area may be thickened, warm, and tender. In the case of a rupture, the fetlock will sink toward the ground.

VetStem Cell Therapy for Suspensory Ligament Injuries

VetStem Cell Therapy has been shown to be an effective treatment option for some suspensory ligament injuries. Treatment with stem cells may reduce inflammation and scar tissue and may also lead to tissue regeneration. In a retrospective review of 62 cases of suspensory ligament injury in sport horses treated with VetStem Cell Therapy, nearly 76% of treated horses returned to full work at their prior level of performance. Additionally, another 16% returned to full work at a lower level of performance. Furthermore, 92% of the horses with acute injuries and over 71% of the horses with chronic injuries returned to their prior level of performance after treatment.

It is important to remember that outcomes vary and not all horses will respond to treatment with VetStem Cell Therapy. In the aforementioned retrospective review, 5 of the 62 treated horses were non-responsive.

If your horse has an injured suspensory ligament and you are curious about whether he/she may benefit from VetStem Cell Therapy, speak to your veterinarian. You can also contact us to receive a list of VetStem providers in your area.

November is National Senior Pet Month, and we want to show those frosted-faces some extra special attention in this week’s blog! Like people, increased age is a risk factor associated with osteoarthritis. One study conducted in the UK indicated that dogs over eight years old were most frequently diagnosed with osteoarthritis. The same study found that dogs over twelve years had the greatest odds of being diagnosed with osteoarthritis compared to other age groups. These findings support the notion that osteoarthritis is predominantly a disease of aging.

Osteoarthritis is the Number 2 Reason for Euthanasia

Given that approximately 1 in 5 dogs in the United States are affected by osteoarthritis, it comes as no surprise that the disease has previously been labeled as the second most common reason for euthanasia. Though there are several treatment options available to help alleviate the symptoms of arthritis, many of them come along with unpleasant side effects and/or begin to lose efficacy after prolonged use.

VetStem Cell Therapy for Osteoarthritis

While it is not a cure for osteoarthritis, as there is no cure for this progressive disease, many arthritic pets have benefited from treatment with VetStem Cell Therapy. Based on information obtained from veterinarians and dog owners, 81% of arthritic older dogs who were treated with VetStem Cell Therapy experienced an improved quality of life. In addition, 63% were not re-treated in the first year, meaning the benefits of stem cell therapy lasted longer than a year. Below are some additional numbers regarding older dogs who received VetStem Cell Therapy for osteoarthritis.

Is VetStem Cell Therapy Right for your Senior Pet?

Though stem cell therapy may lead to a better quality of life in some pets, it may not be the best option for your pet if they do not tolerate anesthesia well or if they have active cancer, which is more prevalent in older pets and is contraindicated with VetStem Cell Therapy. Thus, if you think your pet may benefit from treatment with stem cells, the first place to start is talking with your veterinarian. He/She can perform a comprehensive exam to determine if your pet may be a good candidate for stem cell therapy.

Need to find a vet who provides VetStem Cell Therapy? Click here.

One topic we have not covered is wound healing. Chronic wounds can be a major problem for pets and present many challenges for veterinarians. Some wounds require significant ongoing medical care which can be both stressful and expensive for pet owners.

Stem Cell Therapy for Wound Healing

Stem cells have many potential uses. Veterinarians primarily use VetStem Cell Therapy to treat orthopedic conditions as well as some internal medicine conditions. Stem cells have shown the ability to reduce inflammation and pain and to lead to tissue regeneration. Adipose-derived stem cells can differentiate into multiple tissue types, including skin. Stem cells also release growth factors and cytokines, which the body uses to promote healing.

There is a growing body of evidence demonstrating the potential efficacy of stem cell therapy for wound healing. That being said, there is still significant research to be done before any claims of definitive treatment can be made. While the research continues, some veterinarians (and human physicians) are using stem cell therapy experimentally to help with wound healing.

Jaguar Receives Stem Cell Therapy for Severe Burns

In September, a story came out about a jaguar who was severely burned in a wildfire in Brazil. Amanaci, whose name means “goddess of the waters”, was found in an abandoned hen house amidst the fires in the Pantanal wetlands. She had third-degree burns on all four paws and on her belly. Her mammary glands were swollen with milk, indicating she recently had cubs. Veterinarians speculated that Amanaci spent considerable time trying to protect and save her cubs, which is why she was burned so badly. Unfortunately, no cubs were found.

Amanaci was transported to the NEX Institute where veterinarian, Daniela Gianni and several others took over her care. Dr. Gianni, who has previous experience using stem cell therapy in large cats, treated Amanaci’s wounds with multiple rounds of stem cell treatments along with other therapies due to the severity of her condition. And though her treatment is progressing well, it is believed she is not capable of surviving in the wild at this point. Amanaci will likely continue living at the institute along with 23 other jaguars. To read more about Amanaci’s story, click here. Or click here to watch a brief video.

Yesterday, October 29^th, was National Cat Day! We could not let this holiday pass by without a shout out in our blog! We at VetStem love cats and employ quite a few self-professed “crazy cat ladies.”

National Cat Day was created to bring awareness to the many cats that need rescuing each year and to “encourage cat lovers to celebrate the cat(s) in their life for the unconditional love and companionship they bestow upon us.” According to the American Veterinary Medical Association (AVMA), in 2017-2018 over 25% of the households in the United States owned cats. With over 30 million households owning an average of 1.8 cats, that means there were nearly 60 million family cats in the United States at the time of the AVMA’s pet ownership survey. That is a lot of cats!

Regenerative Medicine for Cats

To honor our feline friends, we have compiled a review of stem cell uses for cats. Like dogs and horses, cats may benefit from VetStem Cell Therapy for arthritic joints or injured tendons and ligaments. In addition, many veterinarians have used VetStem Cell Therapy in cats for kidney disease, gingivostomatitis, and inflammatory bowel disease.

Osteoarthritis

Though we tend to think of dogs when it comes to arthritis, cats are susceptible to the disease as well. Unlike some dogs, cats are very good at hiding their pain. If you are unsure if your cat is in pain, speak to your veterinarian. We’ve also written a few blogs on the topic: click here and here to learn some of the possible signs of pain in cats.

Though most of our osteoarthritis data is from dogs, cats have experienced similar results when treated with VetStem Cell Therapy. Stem cells may reduce pain and inflammation associated with osteoarthritis and may lead to the regeneration of damaged joint tissues. This can result in increased mobility and a better quality of life for your kitty.

Kidney Disease

Nearly 200 cats have received VetStem Cell Therapy for chronic kidney disease (CKD). CKD is a common cause of sickness and death in cats. In fact, some reviews suggest that CKD may be the number one cause of sickness and death in older cats. Unfortunately, treatment options are limited and can be costly.  

VetStem veterinarians have seen some promising results in the treatment of feline CKD. Based upon data from a small number of feline patients treated with VetStem Regenerative Cell Therapy, blood kidney values were slightly to moderately improved after treatment. While more evaluation is necessary, these preliminary results suggest that stem cell therapy may be a low-risk treatment option for cats with CKD.

Gingivostomatitis

Another debilitating feline disease is gingivostomatitis, which affects the gums, teeth and sometimes upper throat of cats. Gingivostomatitis causes oral pain which leads to other symptoms such as decreased appetite, reduced grooming, and weight loss. The most common treatment is extracting all the cat’s chewing teeth, however only about 70% of cats will respond to this treatment. The remaining 30% of cats that do not respond will require lifelong treatment with medications.

Some veterinarians have seen favorable results using VetStem Cell Therapy in cats affected by gingivostomatitis. In addition, two small studies conducted at the University of California Davis showed that when fat-derived stem cell therapy was utilized in addition to teeth extractions there was improvement or remission in the majority of cats treated. VetStem believes that fat-derived stem cell therapy without full extractions may be beneficial.

Inflammatory Bowel Disease

Inflammatory Bowel Disease (IBD) is a gastrointestinal disease that can affect both cats and dogs. It is characterized by inflammation of the intestines and can cause vomiting, diarrhea, reduced appetite, and weight loss. It is important to note however, that these symptoms can be indicative of several conditions including feline lymphoma. Since VetStem Cell Therapy is contraindicated in pets with cancer, it is essential to rule this out before pursuing treatment with stem cells.

Several cats have received VetStem Cell Therapy for IBD. In a case study where a 4-year-old Himalayan cat developed IBD, treatment with VetStem Regenerative Cell Therapy quickly resolved the cat’s diarrhea and vomiting and led to an increased appetite with no recurrence. To add to that, in a recently published paper, 5 out of 7 cats that were treated with stem cells were significantly improved or had complete resolution of symptoms, whereas the 4 control cats had no improvement. One of our veterinary clients also wrote a guest blog about one of his feline patients who received VetStem Cell Therapy for IBD.

If you believe your cat may benefit from VetStem Cell Therapy, speak to your veterinarian. Or contact us to receive a list of VetStem providers in your area. Maybe stem cell therapy is just the gift your cat needs for National Cat Day!

We recently brought in a new Safety and Technical Services Veterinarian. We are so excited to welcome Dr. Amber Vibert to the VetStem team! Learn more about Dr. Vibert and her veterinary experience in this week’s blog!

Shifting Gears: Deciding to Pursue Veterinary Medicine

Dr. Vibert grew up in Connecticut and is a diehard fan of the New England Patriots- even without Tom Brady, if you can believe that (though she concedes that she misses him terribly). Unlike many veterinarians, Dr. Vibert did not grow up with the intention to become a veterinarian. It was quite the opposite.

After receiving her Bachelor’s in clinical psychology with a focus on child development, Dr. Vibert planned to pursue a master’s degree in social work. However, one day she literally woke up and decided to pursue veterinary medicine after realizing that her most stimulating and rewarding job was that of an entry-level veterinary assistant when she was a senior in high school. And so she got a full time position as a vet assistant at a multi-doctor private practice and went back to school part time to complete the higher level science courses she needed to gain acceptance to veterinary school.

From Vet School in Indiana to Sunny San Diego

She completed the necessary schooling in three years and was accepted to Purdue University upon her first application. After her first year of vet school, she visited San Diego and fell in love with the palm trees, the beaches, and of course, the weather. Spending four years in the Midwest while at Purdue made Dr. Vibert miss the ocean. Having grown up on the coast of CT, the ocean was a huge part of her childhood. And while she misses the seasons and charm of New England, she certainly does not miss the long and cold winters. And so, upon graduation from vet school in 2006, Dr. Vibert planted her roots in sunny San Diego!

Gaining Experience in Emergency Medicine and General Practice

When she arrived in San Diego, Dr. Vibert completed a rotating internship at Veterinary Specialty Hospital and went on to spend several years as an emergency veterinarian. She enjoyed the fast pace and the quick decision making of emergency medicine. She stated, “For me, a successful outcome felt like winning the World Series or the Super Bowl!” She also honed her surgical skills and developed a passion for all types of soft tissue surgeries.

In 2011, she shifted gears into general practice. She enjoyed the relationships she built with her clients and their pets. In some cases, she felt like a part of their family. Dr. Vibert stated, “People revealed to me very personal things about their lives, which can sometimes take its toll (i.e. compassion fatigue), but more often just helped me understand them and care for them on a personal level. I became that much more invested in the well-being of their beloved pet.” Prior to joining VetStem, Dr. Vibert spent the last year and a half as Medical Director of a multi-doctor, small animal practice.

Joining the VetStem Team

Now, as our Safety and Technical Services veterinarian, Dr. Vibert has entered a whole new realm of veterinary medicine. Regarding joining the VetStem team, Dr. Vibert stated, “I am so excited to be learning so many new things at VetStem! Some of these things are obvious- learning about stem cells and their applications, learning about our laboratory processes and practices- but I’m also learning things like new computer software systems, how to write scientific papers, and organizing collaborative efforts on clinical development projects. I’m using my brain in ways that I never really had time to do in clinical practice!”

Dr. Vibert serves as our veterinary liaison to further develop relationships with existing and new veterinary clients. With an emphasis on safety, Dr. Vibert consults with veterinarians on stem cell and platelet therapy cases to provide insight and treatment recommendations. She stated, “I am excited for the opportunity to contribute to the betterment of animal and human lives by way of regenerative medicine. I am also looking forward to forging new professional relationships with the veterinarians whom VetStem serves.”

Outside of Veterinary Medicine

In her spare time, Dr. Vibert enjoys endurance running, horseback riding, cooking, traveling, and spending quality time with her husband, Tim. She has her own menagerie of pets that keep her laughing every day. These include one dog (Rally), two cats (George and Stevie Nicks, “Stevie”), one horse (Valor), and two rats (Igor, “Iggy” and “Luka”).

She has had several rats over the last few years (their average life span is ~2.5-3 years) and believes rats are hands down the best small mammal pets to have. She stated, “Rats are smart, social, affectionate, and very trainable. People who don’t know much about domestic rats are sometimes scared or feel adverse to them, but once you get past the stigma that they are dirty (which is very untrue- they are incredibly clean little animals) and get past the hairless tail, you will discover what awesome pets they make!”

So there you have it. Please send a warm welcome to Dr. Vibert and go get yourself a pet rat!

Hi everybody! Kristi Hauta here, Director of Commercial Operations. I hijacked Dr Harman’s blog this week to give you a little update on my newest furry family member!

Like many people, the social distancing and stay at home orders over the past 7 months has caused stress and anxiety for me and my family. All the uncertainty about what was going to happen next had us in a funk. So, like many others, we decided to get a puppy to brighten up our lives! Granted, it wasn’t entirely spontaneous. We have been contemplating a new dog for several years, we just hadn’t decided on one yet.

At the beginning, we were considering several small breeds. But in the end, we decided that a Newfoundland was the right choice for us. And so…Meet Elphie: the 8-month-old, 80-pound, Goofy Newfie! Now, I will tell you, the biggest dog I have ever owned was a beagle, so I really wasn’t sure what to expect with Elphie. But, even with her lumbering size, she is by far the sweetest and most gentle dog I have ever had the pleasure of owning.

Well, this past week, it was time to get Elphie spayed. Because of her size and the breed’s disposition, I also elected to have a gastropexy done, a surgical procedure to help prevent bloat. Since she was already going to be anesthetized, I asked her veterinary surgeon, Dr. Holly Mullen, to collect some of Elphie’s fat for stem cell therapy. The fat was processed by our wonderful and experienced lab techs here at VetStem, and Elphie’s stem cells were extracted and concentrated.

Because she had just undergone multiple abdominal surgeries, I felt Elphie could benefit from a dose of her stem cells to help with post-surgical healing. The day after her procedure, Elphie received one intravenous dose of her own stem cells. These cells, when introduced into the body, have the ability to home to areas where inflammation is present and to down-regulate inflammation and pain. Furthermore, stem cells may improve the quality of healing with the ability to regenerate tissue and reduce scar tissue formation.

In addition to her single IV dose, Elphie has numerous stem cell doses cryopreserved at VetStem. Due to her large size, she is likely to experience osteoarthritis as she ages. Knowing I have cells stored for Elphie for potential future use is priceless to me. Not only can these cells be used for arthritis, but we are always investigating new diseases that stem cells can be used to treat. Some of our current “Clinical Research Programs” include inflammatory bowel disease (canine and feline), canine back pain, and canine dry eye. While I hope Elphie remains healthy and never has a need for her stem cells, it does make me feel better knowing that option is available.

Though I elected to treat Elphie with one stem cell dose to aid her post-surgical healing, we also offer a process called StemInsure. Similar to storing your (human) baby’s stem cells at birth, the canine StemInsure process provides peace of mind with banked stem cells that can be used later in life. The StemInsure is similar to our standard stem cell process in which we extract stem cells out of your dog’s own fat, however doses are not prepared for immediate treatment. Instead, the cells are placed into cryopreservation and can be cultured to grow usable stem cell doses in the future. The great thing about the canine StemInsure is the fat can be collected in conjunction with an already scheduled, routine procedure such as a spay or neuter.

If you are interested in stem cell therapy for your dog, cat, or horse, speak to your veterinarian or contact us for a list of VetStem providers in your area.

Over the past 10 years, there has been a significant increase in pet obesity rates according to a report conducted by Banfield Pet Hospital. In this report, Banfield determined obesity is the second most common health problem in our pets with 1 out of 3 dogs and cats (in the Banfield population) classified as overweight.

Obesity may cause or exacerbate multiple health issues, including osteoarthritis. Osteoarthritis is a painful inflammatory condition of the joints that is progressive, meaning without intervention it continues to get worse over time. One of its most significant contributing factors in dogs and cats is being overweight. In fact, dogs that are overweight or obese are 2.3 times more likely to be diagnosed with osteoarthritis. That means an overweight dog is more than twice as likely to suffer from this painful disease than a dog of ideal weight. With obesity in pets on the rise, it makes sense that osteoarthritis is also on the rise.

The link between obesity and osteoarthritis is an unfortunate vicious cycle: Weight gain causes more wear and tear on your pet’s joints, leading them to be less active and potentially gain more weight. Likewise, sore joints can lead a pet to be less active which can then lead to weight gain. If weight is not lost, the cycle will continue.

Furthermore, reduced activity often leads to more stiffness and pain. As we discussed in this blog, regular exercise tailored to your dog’s breed and physical abilities may reduce the severity or even delay the onset of osteoarthritis. Regular physical activity helps to build and maintain muscle mass as well as aid in joint fluid circulation, both of which support healthier joints.

If you are unsure if your pet is overweight or suffering from osteoarthritis, consult this blog and speak with your veterinarian. Oftentimes pet parents are unaware that their furry family member is overweight or uncomfortable. Veterinarians are trained to assess your pet’s Body Condition Score or “BCS” (see BCS charts for Dogs and Cats to learn more) and detect pain during their physical exam. In addition to increasing controlled exercise, calorie control is also essential. Your veterinarian can help create a diet plan specific to your pet’s needs. Maintaining an ideal body weight is crucial in minimizing discomfort related to osteoarthritis.

If your dog or cat needs more help with his/her osteoarthritis beyond weight loss and customary medications, consult with a veterinarian regarding treatment with VetStem Cell Therapy. Stem cells have demonstrated the ability to reduce pain and inflammation and to aid in the repair of damaged joints. Need a list of VetStem providers in your area? Contact us here.

We frequently share stories about dogs that received VetStem Cell Therapy for orthopedic conditions such as osteoarthritis and injured cruciate ligaments. But stem cell therapy may potentially help a number of other conditions. Veterinarians have used VetStem Cell Therapy to treat various diseases including renal failure, inflammatory bowel disease, gingivostomatitis, and dry eye.

VetStem Clinical Research Programs

All of the above diseases fall under our Clinical Research Programs. These programs are designed to evaluate the safety and possible effectiveness of stem cell therapy for specific conditions before we move on to performing a clinical trial. Another current Clinical Research Program is for Canine Back Pain. This is obviously a broad condition so feel free to read our blog about this particular program. One condition that falls under the Canine Back Pain program is Intervertebral Disc Disease.

Intervertebral Disc Disease

Intervertebral Disc Disease (IVDD) is a condition in which one or several intervertebral discs in the spine bulge, resulting in pressure on the spinal cord. This pressure may result in extreme pain and possibly loss of limb function. IVDD can be a result of chronic disc degeneration or from an acute injury. Conservative treatment with pain medications and anti-inflammatories may help patients who have a gradual onset of symptoms or whose symptoms are mild. In severe cases or when there are repeated episodes, surgery may be recommended.

Bailee Received VetStem Cell Therapy for IVDD

Bailee, an English Springer Spaniel, was approximately fourteen years old when he injured his neck. He jumped off a deck that was about four feet off the ground and yelped in pain. He was diagnosed with IVDD and was prescribed pain medications. Unfortunately, the medications made him very lethargic and did not help his pain so his owner sought a second opinion.    

Dr. Susan Burkhart of Animal Medical Center of Ontario examined Bailee and recommended treatment with VetStem Cell Therapy. Within one week after his stem cell therapy, Bailee’s owner reported that she noticed a huge difference. She stated, “He was once again smiling, and out of pain. It has been 2.5 years since then, and Bailee is one happy pup, once again, and able to live many more years pain free. I am so grateful and would do again for any of my pets.”

While stem cells have demonstrated the ability to reduce pain and inflammation, there is limited data to support the use of stem cell therapy for the treatment of IVDD. Since this condition develops for different reasons, the stem cell protocol and outcome can vary for each dog. Any inquiries regarding treatment of similar conditions or other non-standard indications should be directed to VetStem personnel.

If you have some time, click the picture below to view a recent webinar from VetStem CEO Dr. Bob Harman. Dr. Harman discusses VetStem Cell Therapy in depth and also gives tons of information about our human stem cell studies including an upcoming FDA approved COVID-19 clinical trial.

In this video you will learn the history of VetStem and what stem cells do to promote healing. You will also learn about the various diseases VetStem Cell Therapy has been used for. If you skip ahead to approximately 14:50, Dr. Harman shifts to discuss our human stem cell company, Personalized Stem Cells, Inc. At approximately 19:00 Dr. Harman begins talking about PSC’s upcoming FDA approved COVID-19 trial. He provides information about recent stem cell studies for COVID-19 and details about the PSC study. You don’t want to miss this!

As Animal Pain Awareness Month continues, we wanted to share some information about how stem cells may relieve pain in pets. We frequently share stories about dogs with osteoarthritis who regain mobility and a better quality of life after receiving VetStem Cell Therapy. While stem cells utilize multiple mechanisms of action, one primary benefit of stem cells is their ability to reduce inflammation and pain.

Pain in Pets

As we mentioned in last week’s blog, pets can suffer from acute and chronic pain. Pain in pets can result from a variety of causes and there are three primary classifications of pain:

• Nociceptive – caused by noxious stimulation (injury/physical damage, exposure to chemicals or exposure to extreme temperatures)
• Inflammatory – caused by acute or chronic inflammation
• Neuropathic – from damage to an element of the nervous system

Stem Cells are Anti-Inflammatory

One major mechanism of action is the ability of stem cells to down regulate inflammation. By reducing inflammation, stem cells promote healing and increase comfort. When used to treat osteoarthritis, stem cells may promote cartilage regrowth and therefore healthier and less painful joints.

Stem Cells Act Directly on Pain

While a reduction in inflammation can lead to increased comfort, current literature supports that stem cells have the ability to address both acute and chronic pain directly. Recently, there have been studies to evaluate stem cells’ direct effects on modulating pain. Stem cells have been shown to secrete pain blocking cytokines (small proteins), which can have opioid-like effects. Stem cells have also shown the ability to reduce neuroinflammation (inflammation of the nervous tissue).

If you think your pet may benefit from stem cell therapy, contact us for a list of VetStem providers in your area.