We’re back with another pain-themed blog for Animal Pain Awareness Month. This week, we are discussing VetStem Cell Therapy as a means to control pain in pets. While stem cells have many mechanisms of action including the ability to differentiate into many tissue types and stimulate the regeneration of tendon, ligament, and joint tissues, they also have the ability to reduce pain and inflammation.

The ability of stem cells to down-regulate inflammation is important when it comes to pain management. Through cellular communication, stem cells are able to limit inflammatory responses and actually shift from a pro-inflammatory environment to an anti-inflammatory environment. By reducing inflammation, stem cells promote healing and increased comfort.

While a reduction in inflammation can lead to increased comfort, current literature supports that stem cells also have the ability to address both acute and chronic pain directly. Stem cells have shown to secrete pain blocking cytokines (small proteins), which can have opioid-like effects. Interestingly enough, these effects can actually be reversed by Naloxone, an opioid antagonist.

This helps to explain why we consistently hear from pet owners and veterinarians alike that patients treated with VetStem Cell Therapy for things like osteoarthritis or injured cruciate ligaments, experience increased comfort within just days of receiving treatment. By directly decreasing the pet’s pain, their comfort level goes up while the stem cells continue to perform their healing duties.

Thousands of animals have experienced a better quality of life as a result of treatment with VetStem Cell Therapy. Stem cells have the advantage of being a readily available, natural source of anti-inflammatory and pain blocking cells. This can be especially beneficial for cats and some dogs who do not tolerate pain medications well. If you think your pet may benefit from VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers near you.

For those who missed our last few blogs, September was declared Animal Pain Awareness Month by the International Veterinary Academy of Pain Management (IVAPM). Animal Pain Awareness Month was established to raise awareness and to help veterinary professionals and pet owners recognize and manage pain in animals.

Unfortunately, recognizing pain in our pets is not always easy. Some instances of acute pain are likely to be more obvious, such as pain from an injury or surgical procedure. However chronic pain tends to come on more slowly and thus, we may not recognize the signs for a while. An example of chronic pain is pain from osteoarthritis.

As part of their efforts to educate pet parents about recognizing pain in pets, the IVAPM has a list of the most common signs of pain. They are:

• Decreased activity – Take notice if your animal is not playing as much as usual
• Not going up or down stairs – This could be an early sign of osteoarthritis
• Reluctance to jump onto surfaces – This especially applies to cats
• Difficulty standing after laying down – This is a sign of osteoarthritis
• Decreased appetite – This can signal mouth pain
• Over grooming or licking a particular area – This can be a sign of referred pain

For a more comprehensive list of the common signs of pain in dogs and cats, visit the IVAPM website.

Additionally, they have put together checklists for dogs and cats that can be used to help determine if your pet is in pain.

While September is Animal Pain Awareness Month, it’s a good idea to keep an eye out for these potential signs of pain at all times. If you notice that your pet is exhibiting any of these signs, a trip to your vet may be in order.

As discussed in last week’s blog, September is Animal Pain Awareness Month. Animal Pain Awareness Month was created by the International Veterinary Academy of Pain Management (IVAPM) and is dedicated to raising awareness to help veterinary professionals and pet owners recognize and manage pain in animals. But who is IVAPM? In this week’s blog, we will discuss the IVAPM and their important mission in veterinary medicine.

Who is IVAPM?

The International Veterinary Academy of Pain Management (IVAPM) was founded in 2001 by a group of veterinarians, including one of VetStem’s earliest users and collaborators, Dr. Jamie Gaynor. The organization evolved over the years and today, is led by an active board of directors to provide veterinary pain management education as well as a pain management certification program. The current president of IVAPM, Dr. Douglas Stramel, is also an avid VetStem user.

The IVAPM unites veterinary professionals across all disciplines from around the world to advocate for best practices in the treatment of pain in animals. The organization is committed to encouraging pain management for all animal species through education and advocacy. They also encourage various veterinary organizations to raise public awareness about pain and pain management as it pertains to veterinary patients. IVAPM is the leading forum and educational resource for veterinary professionals and pet owners interested in animal pain prevention, management, and treatment.

IVAPM Pain Management Forum

One of the primary goals of IVAPM is to educate the veterinary community to recognize and treat pain in all species of animals. IVAPM provides continuing education on a variety of topics around the world. As mentioned above, they also provide the only interdisciplinary pain management certification program for veterinary professionals.

In addition to these efforts, IVAPM puts on an annual Pain Management Forum to bring together like-minded veterinary professionals who all advocate for the best practices in the treatment of animals in pain. In both 2022 and 2023, VetStem exhibited and sponsored labs at the Forum. 2024 will bring the third annual Pain Management Forum.

Resources for Pet Owners

The IVAPM does not solely focus on educating veterinary professionals. Pet owners play a key role in both recognizing and managing their pet’s pain. Thus, the IVAPM has several resources for pet owners as well. Through their website, pet owners can search for Certified Veterinary Pain Practitioners and also find various resources to help determine if a pet is in pain.

September is here and as some of you may know, this month is very important in the veterinary world. September has been declared as Animal Pain Awareness Month by the International Veterinary Academy of Pain Management (IVAPM). The goal of this month is to raise awareness and to help veterinary professionals and pet owners recognize and manage pain in animals of all species. As such, each year, we dedicate the entire month of VetStem blogs to the topic.

Pain Management in Pets

Just like people, pain in our pets can lead to a decreased quality of life. By managing an animal’s pain, we not only make them feel better, but we also help them live a happier life. IVAPM works to educate veterinary professionals and pet owners to better understand how to recognize and manage pain in pets and, in doing so, has helped the field of veterinary pain management grow tremendously in recent years.

As the field continues to grow, there have been a great many advances for methods to control pain in animals. Pain medications are no longer the only way to control pain. Several newer and more natural alternatives have become more mainstream in veterinary medicine including things like rehabilitation, acupuncture, and even stem cell therapy. With these advances, veterinarians now have the ability to help several different painful conditions that they struggled with in the past.

Types of Pain in Pets

It is important to note that there are multiple types and causes of pain in animals. Pain can be acute such as pain from a recent surgical procedure or injury. Acute pain is characterized by pain that has come on suddenly or has only been present for a short period of time. Alternatively, chronic pain can be more subtle and likely came on slowly over an extended period of time. An example of chronic pain is osteoarthritis pain.

We can further break this down into types of pain. The three primary classifications of pain are nociceptive, inflammatory, and neuropathic. Nociceptive pain is caused by noxious stimulation such as an injury/physical damage, exposure to chemicals, or exposure to extreme temperatures. As its name suggests, inflammatory pain is caused by acute or chronic inflammation. And lastly, neuropathic pain comes from damage to an element of the nervous system.

Understanding the types and causes of pain in pets can help pet owners recognize when their pet may be in pain and when to seek help from their veterinarian. Pain management is an invaluable tool in maintaining happy and healthy pets. Stay turned for more pain awareness blogs all month long!

This week, we are debuting our latest product, PrecisePRP™, at the Fetch DVM360 veterinary conference in Kansas City, MO. This is our first conference since we launched the product, and we are very excited to get in front of veterinarians and technicians to explain what a game-changer PrecisePRP™ is for the industry!

Platelet-rich plasma (PRP) is defined as concentrated platelets in plasma. It is a therapeutic regenerative medicine modality that is commonly used to treat joint disease, such as osteoarthritis, as well as soft tissue injuries (tendon, ligament), and wounds. Unfortunately, there are several variables that can affect the concentration of platelets used for treatment, which can then affect the treatment outcome.  

How is PRP Produced?

Platelet-rich plasma is most frequently produced in the veterinary clinic using a pet’s own blood. The blood is drawn from the patient then filtered or centrifuged using a mechanical PRP kit. There are several mechanical PRP kits on the market currently, each of which requires a unique processing method. Once the blood is run through the kit, the end result is PRP, which is then injected directly into the problem area (i.e., joint, tendon lesion, wound, etc.).

Disadvantages of Mechanical PRP Kits

There are several disadvantages that come with producing PRP using a mechanical kit. Perhaps the most significant of these is the variability of the final PRP used to treat the patient. Numerous factors can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. Ultimately, if the PRP doesn’t contain what is considered a therapeutic dose of concentrated platelets, the patient likely won’t experience much relief.

This variability was made apparent when, in researching PRP kits, we performed a comparison of four PRP kits for the production of equine PRP. Each kit demonstrated a lack of uniformity relating to the final platelet count and platelet concentration. Moreover, each kit failed to meet their respective platelet concentration claim.

Consistency with PrecisePRP™

We didn’t feel comfortable selling PRP kits that would potentially lead to poor treatment outcomes. So instead, we invented PrecisePRP™, a freeze-dried donor-derived platelet-rich plasma currently available in a dog and horse format. PrecisePRP™ Canine and PrecisePRP™ Equine do not require processing to produce PRP, instead your veterinarian will simply rehydrate and inject.

Each vial of PrecisePRP™ undergoes rigorous quality testing to meet precise product release specifications. This results in a uniform and consistent PRP product, eliminating the variability mentioned above so that veterinarians know exactly what they’re injecting every single time. PrecisePRP™ donors are screened according to FDA Center for Veterinary Medicine guidance and in controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™.

Veterinarians interested in purchasing PrecisePRP™ should contact Customer Service.

In last week’s blog, we discussed kidney disease in cats and how VetStem Cell Therapy may help. This week, we want to discuss osteoarthritis (OA) in cats so that cat owners know what to watch out for. That’s right, cats get OA too! In fact, a high percentage of cats will get or already have osteoarthritis. According to one study, 91% of cats between 6 months and 20 years old have OA in at least one joint, as proven by X-rays.

National Take your Cat to the Vet Day

But why two cat blogs in a row, you ask? Well August 22^nd is National Take your Cat the Vet Day. This day is meant to bring awareness to the fact that the statistics for feline veterinary care are disparagingly low compared to dogs. According to one recent academic survey, only 20% of cat owners said they took their cat to the vet more than once a year, compared to 35% of dog owners. Additionally, 7% of cat owners said they never seek veterinary care, compared to 2% of dog owners. Likewise, in a targeted survey of pet owners conducted by the AVMA, only 48% of cat owners said they sought routine veterinary care for their cat, compared to 79% of dog owners.

Cats are Masters at Hiding Their Pain

There are likely several reasons for this discrepancy, one of which may be the fact that cats tend to be masters at hiding their pain. This tendency is often linked to survival instincts. In the wild, if a cat shows weakness, this may draw unwanted attention from a predator. But in the domestic cat whose only predator is a half empty bowl of food, this tendency to hide pain just means us owners have a hard time knowing when our cat should be taken to the vet.

Preventative Veterinary Care for Cats

Thus, National Take your Cat to the Vet Day promotes the idea of once-to-twice yearly preventative veterinary exams. These types of routine check-ups are important to maintain a cat’s health. Even if nothing appears to be wrong with your cat, routine examinations by your veterinarian may uncover some ailment that your cat has been hiding. In the same way, routine bloodwork can help your veterinarian monitor for diseases such as kidney failure.

Symptoms of Osteoarthritis in Cats

But back to OA in cats. For years, osteoarthritis in cats has been underdiagnosed when compared to dogs. One reason for this is that cats with OA present with different symptoms than what we see in dogs. Because of their smaller size and natural agility, cats tend to tolerate bone and joint problems better than dogs. But there are specific symptoms to watch out for.

According to the FDA, “Clinical signs of osteoarthritis in cats include weight loss, loss of appetite, depression, change in general attitude, poor grooming habits, urination or defecation outside the litter pan, and inability to jump on and off objects.” Unlike dogs, cats do not commonly present with lameness or limping. Instead, they will be less willing to jump and/or have shorter jumps.

Treatment for Osteoarthritis in Cats

Unfortunately, there are fewer treatment options for cats with OA compared to dogs. Unlike dogs, cats do not tolerate nonsteroidal anti-inflammatory drugs (NSAIDs) or other pain medications very well. While there are some NSAIDs approved for short-term post-operative use in cats, there are currently no veterinary NSAIDs approved for safe, long-term use to control osteoarthritis pain in cats. There are some non-drug options including weight loss for overweight cats, increased exercise, as well as environmental accommodations such as elevated food bowls and more easily accessible litter boxes. But these are not the only non-drug treatment options available.

VetStem Cell Therapy for Osteoarthritis in Cats

VetStem Cell Therapy is a non-drug treatment option for osteoarthritis in cats, dogs, and horses. It can be particularly beneficial for cats, given that effective treatment options to control osteoarthritis pain are extremely limited. Stem cells have shown the ability to directly modulate pain and down-regulate inflammation. Additionally, stem cells can induce repair and stimulate regeneration of cartilage and other joint tissues. The beauty of VetStem Cell Therapy is that we are harnessing your pet’s own healing power, so it can be considered a natural and holistic approach to managing the symptoms of osteoarthritis.

If you are interested in having your pet treated with VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers in your area.

VetStem Cell Therapy, while commonly used to treat orthopedic conditions in dogs and horses, has also been successfully used to treat a number of other diseases. One such disease is kidney disease in cats. Nearly 250 cats have received VetStem Cell Therapy for kidney disease.

Kidney disease is one of the most common causes of sickness and death in cats. Common symptoms can include weight loss, lethargy, variable appetite, and poor coat quality. Some cats may also drink and urinate more, vomit, or have diarrhea.

Unfortunately, treatment options for cats with kidney disease are limited and can be costly. The good news is, based upon our own data as well as the data of others, we believe that stem cells may help improve the symptoms and quality of life in some cats with kidney disease. In fact, a review of a small number of feline patients treated with VetStem Cell Therapy showed that blood kidney values were slightly to moderately improved after treatment.

Anecdotal data from pet owners and veterinarians suggests that treatment with VetStem Cell Therapy helps to improve symptoms associated with kidney disease. Owners have reported improved appetites, weight gain, and increased energy. That being said, more data is necessary regarding the use of VetStem Cell Therapy for cats with kidney disease. Thus, we continue to research the use of stem cells for this condition under one of VetStem’s clinical research programs.

If you think your cat may benefit from treatment with VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of qualified VetStem providers near you.

August 4^th is Assistance Dog Day and next week is International Assistance Dog Week. This is a time to recognize and honor the hard work and selfless love that assistance dogs provide day in and day out. As you probably know, assistance dogs are specially trained to perform specific tasks for people with disabilities. These disabilities can be physical, sensory, psychiatric, intellectual, or mental. There are many types of assistance dogs including guide dogs for the blind, medical and hearing alert dogs, mobility assistance dogs, and more. In this week’s blog, we are going to share a special story about a psychiatric service dog named Max.

Max has been a trained companion for U.S. Army Staff Sergeant Edward Johnson since 2014. Sgt. Johnson, a purple heart recipient, was shot in the head during combat in Iraq in 2006 and was left with a traumatic brain injury. Max helps Sgt. Johnson cope with PTSD and other debilitating ailments related to his injuries.

Unfortunately, Max tore his cruciate ligament in his knee. As a common injury in large breed dogs, cruciate ligament tear is one of the biggest reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs. Additionally, according to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future.

Max was obviously in pain and in need of surgery and other medical procedures. Fortunately, his story made the news and through donations and good will, Max was able to have surgery and treatment with VetStem Cell Therapy. His surgeon, Dr. Jeff Christiansen of Superior Veterinary Surgical Solutions, donated his services and organized donations from several others as well. As an experienced VetStem provider, Dr. Christiansen recommended stem cell and platelet therapy in conjunction with the surgery to aid Max’s healing. VetStem provided a free platelet therapy kit as well as discounted stem cell processing services.

According to Dr. Christiansen, Max recovered completely. But as is common, Max suffered a second cruciate ligament rupture in his other leg just over two years after his first surgery. Once again, Dr. Christiansen and several companies, including VetStem, stepped up to provide this dog with top-notch care. Max received surgery on his other knee in addition to stem cells and platelet therapy. Max once again recovered well and hasn’t required a repeat stem cell treatment since.

While we primarily focus on stem cells, another exciting tool in the regenerative medicine bucket is platelet-rich plasma (PRP). PRP is defined as concentrated platelets in plasma. But what does PRP do and what can it be used to treat?

The Healing Properties of Platelets

To understand how PRP works, we first need to understand what platelets do in the body. Platelets are very small cells found in the blood stream of mammals and are best known for their ability to clot the blood. However, there is much more that these tiny but powerful cells can do. A complex signaling system sent out from damaged cells attracts platelets to an injury and tells them to release several healing molecules that they have stored inside of them. In turn, these healing molecules attract a multitude of additional healing cells (including stem cells) to the site of injury or inflammation. Together, these cells have been shown to reduce pain, remove the damaged cells, build new blood vessels, prevent further tissue damage, and generate new healthy cells in place of the injured ones.

What can PRP be Used to Treat?

In veterinary medicine, PRP is most often used for orthopedic problems such as cruciate ligament tears, osteoarthritis, and tendon injuries in dogs, cats, and horses. However, recent research has shown that PRP can also aid in the healing of skin wounds, corneal (eye) ulcers, surgical incision sites, tooth sockets following extraction, and even muscle tears. Platelet therapy can also be used in conjunction with VetStem Cell Therapy to maximize the effect of both treatments.

PRP Kits: How they Work and the Associated Disadvantages

Historically, PRP has been produced using the patient’s blood. The blood is run through a mechanical device, or kit, each of which requires a unique processing method. The end result is concentrated platelets in plasma (PRP), however the exact concentration of platelets in the final product is not usually known.

This is perhaps the biggest disadvantage when using kits to produce PRP. There are several variables that can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. In a recent comparison of four PRP kits for the production of equine PRP, these kits demonstrated a lack of uniformity relating to the final platelet count and platelet concentration, and each kit failed to meet their respective platelet concentration claim.

Consistency is Key: PrecisePRP™

Fortunately, VetStem found a way to significantly reduce these disadvantages. PrecisePRP™ is a freeze-dried, donor-derived platelet-rich plasma; truly an off-the-shelf PRP. Each vial of PrecisePRP™ is uniform in platelet characteristics and concentration. This eliminates the variability mentioned above so that veterinarians know exactly what they’re injecting every single time, which can increase positive treatment outcomes. Additionally, PrecisePRP™ is not a kit and does not require processing, making it an easy and convenient alternative to currently available PRP kits.

We took the development of this product very seriously to ensure a positive safety profile. All donors are screened according to the FDA CVM guidance 254. Each batch is sterility, endotoxin, and quality tested to meet precise product release specifications. In controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™. This unique product is currently available in both dog and horse formats.

Pretty exciting stuff! Want to learn more? Visit www.vetstem.com/pprp.php for more information.

A sad story that we hear a lot is when a ball-loving dog is no longer able to play fetch due to arthritis or some other orthopedic injury. That was the case for Sherlock, a nearly 100-pound Staffordshire terrier/rottweiler mix. Though Sherlock loved to chase his ball, as he got older, his body started slowing down and he was diagnosed with arthritis in all four limbs. In an effort to not take away his favorite activity, his owners continued to play ball with a little less intensity. And then he tore his cruciate ligament in his right knee.

Fortunately for Sherlock, his veterinarian recommended using VetStem Cell Therapy in conjunction with surgery. Stem cells have the ability to reduce pain, inflammation, and minimize the formation of scar tissue. In addition to his injured knee, Sherlock’s veterinarian treated both of his elbows and his non-injured knee to give him some relief from the arthritis in those joints.

Sherlock’s owner reported that he responded well to his initial stem cell treatment but that shortly after, he injured the cruciate ligament in his left knee. Unfortunately, this is more common than you may think. According to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future. This time, Sherlock’s veterinarian was able to request doses from his stored stem cells, which she administered during the surgery on his left knee. Sherlock once again received an injection of his own stem cells into each knee and each elbow.

After treatment, his owner said that his recovery went from six weeks to three-and-a-half weeks. She stated, “He healed so quickly that it surprised everyone. He was 12 years old by this time and a full recovery seemed almost too hopeful to wish for, but instead we not only got a full recovery but a faster recovery than before.” She went on to state, “Sherlock is now 13 years old and we do not run and chase balls anymore, but we enjoy walks on the beach and lots of snuggles and I am so grateful that he is still here feeling good and enjoying life with me. Stem cell therapy made an immense difference in his ability to live a high quality life in his older years.”

Does your dog suffer from osteoarthritis or have they injured their cruciate ligament? If so, VetStem Cell Therapy may help. Speak to your veterinarian or contact us to receive a list of VetStem providers near you.