This week, we are debuting our latest product, PrecisePRP™, at the Fetch DVM360 veterinary conference in Kansas City, MO. This is our first conference since we launched the product, and we are very excited to get in front of veterinarians and technicians to explain what a game-changer PrecisePRP™ is for the industry!

Platelet-rich plasma (PRP) is defined as concentrated platelets in plasma. It is a therapeutic regenerative medicine modality that is commonly used to treat joint disease, such as osteoarthritis, as well as soft tissue injuries (tendon, ligament), and wounds. Unfortunately, there are several variables that can affect the concentration of platelets used for treatment, which can then affect the treatment outcome.  

How is PRP Produced?

Platelet-rich plasma is most frequently produced in the veterinary clinic using a pet’s own blood. The blood is drawn from the patient then filtered or centrifuged using a mechanical PRP kit. There are several mechanical PRP kits on the market currently, each of which requires a unique processing method. Once the blood is run through the kit, the end result is PRP, which is then injected directly into the problem area (i.e., joint, tendon lesion, wound, etc.).

Disadvantages of Mechanical PRP Kits

There are several disadvantages that come with producing PRP using a mechanical kit. Perhaps the most significant of these is the variability of the final PRP used to treat the patient. Numerous factors can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. Ultimately, if the PRP doesn’t contain what is considered a therapeutic dose of concentrated platelets, the patient likely won’t experience much relief.

This variability was made apparent when, in researching PRP kits, we performed a comparison of four PRP kits for the production of equine PRP. Each kit demonstrated a lack of uniformity relating to the final platelet count and platelet concentration. Moreover, each kit failed to meet their respective platelet concentration claim.

Consistency with PrecisePRP™

We didn’t feel comfortable selling PRP kits that would potentially lead to poor treatment outcomes. So instead, we invented PrecisePRP™, a freeze-dried donor-derived platelet-rich plasma currently available in a dog and horse format. PrecisePRP™ Canine and PrecisePRP™ Equine do not require processing to produce PRP, instead your veterinarian will simply rehydrate and inject.

Each vial of PrecisePRP™ undergoes rigorous quality testing to meet precise product release specifications. This results in a uniform and consistent PRP product, eliminating the variability mentioned above so that veterinarians know exactly what they’re injecting every single time. PrecisePRP™ donors are screened according to FDA Center for Veterinary Medicine guidance and in controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™.

Veterinarians interested in purchasing PrecisePRP™ should contact Customer Service.

While we primarily focus on stem cells, another exciting tool in the regenerative medicine bucket is platelet-rich plasma (PRP). PRP is defined as concentrated platelets in plasma. But what does PRP do and what can it be used to treat?

The Healing Properties of Platelets

To understand how PRP works, we first need to understand what platelets do in the body. Platelets are very small cells found in the blood stream of mammals and are best known for their ability to clot the blood. However, there is much more that these tiny but powerful cells can do. A complex signaling system sent out from damaged cells attracts platelets to an injury and tells them to release several healing molecules that they have stored inside of them. In turn, these healing molecules attract a multitude of additional healing cells (including stem cells) to the site of injury or inflammation. Together, these cells have been shown to reduce pain, remove the damaged cells, build new blood vessels, prevent further tissue damage, and generate new healthy cells in place of the injured ones.

What can PRP be Used to Treat?

In veterinary medicine, PRP is most often used for orthopedic problems such as cruciate ligament tears, osteoarthritis, and tendon injuries in dogs, cats, and horses. However, recent research has shown that PRP can also aid in the healing of skin wounds, corneal (eye) ulcers, surgical incision sites, tooth sockets following extraction, and even muscle tears. Platelet therapy can also be used in conjunction with VetStem Cell Therapy to maximize the effect of both treatments.

PRP Kits: How they Work and the Associated Disadvantages

Historically, PRP has been produced using the patient’s blood. The blood is run through a mechanical device, or kit, each of which requires a unique processing method. The end result is concentrated platelets in plasma (PRP), however the exact concentration of platelets in the final product is not usually known.

This is perhaps the biggest disadvantage when using kits to produce PRP. There are several variables that can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. In a recent comparison of four PRP kits for the production of equine PRP, these kits demonstrated a lack of uniformity relating to the final platelet count and platelet concentration, and each kit failed to meet their respective platelet concentration claim.

Consistency is Key: PrecisePRP™

Fortunately, VetStem found a way to significantly reduce these disadvantages. PrecisePRP™ is a freeze-dried, donor-derived platelet-rich plasma; truly an off-the-shelf PRP. Each vial of PrecisePRP™ is uniform in platelet characteristics and concentration. This eliminates the variability mentioned above so that veterinarians know exactly what they’re injecting every single time, which can increase positive treatment outcomes. Additionally, PrecisePRP™ is not a kit and does not require processing, making it an easy and convenient alternative to currently available PRP kits.

We took the development of this product very seriously to ensure a positive safety profile. All donors are screened according to the FDA CVM guidance 254. Each batch is sterility, endotoxin, and quality tested to meet precise product release specifications. In controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™. This unique product is currently available in both dog and horse formats.

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Pretty exciting stuff! Want to learn more? Visit www.vetstem.com/pprp.php for more information.