VetStem recently launched two FDA-reviewed platelet-rich plasma (PRP) products: PrecisePRP™ Canine and PrecisePRP™ Equine. PrecisePRP™ is a freeze-dried off-the-shelf PRP unlike any platelet-rich plasma currently on the market. The primary benefits of PrecisePRP™ include ease of use and consistency. With PrecisePRP, you no longer have to draw blood and process it to obtain the PRP. You simply reconstitute and inject. Additionally, PrecisePRP™ provides a consistent dose of PRP so you know exactly what you’re injecting every single time.

After a few months on the market, numerous veterinarians have begun to routinely incorporate PrecisePRP™ into their practice. We recently spoke with board-certified veterinary surgeon and long-time regenerative medicine provider, Dr. Jeff Christiansen, to learn about his use of platelet-rich plasma and to hear his thoughts after using PrecisePRP™. Below, you will find a brief Q&A followed by a link to the video interview, which goes into more depth.

What are the most common injuries/conditions you treat with PRP?

I use PRP primarily in conjunction with surgeries and/or in combination with stem cell therapy. I most commonly use it for cruciate injuries, either with stem cell therapy and/or with surgery (TTA vs. extracapsular). I also use it with medial patellar luxation +/- stem cell therapy. I have used it in cases of hip dysplasia in combination with stem cell therapy. Other arthropathies I have used PRP for include elbow, shoulder, carpus and, less commonly, tarsus. I frequently use PRP with fracture repairs, with both long bone and joint fractures. I also use it for tendon/ligament injuries, such as common calcaneal/Achilles, collateral, etc. And lastly, any reconstructive surgery, tumor removal, resection of inflamed/infected tissue, etc.

What do you like most about PrecisePRP compared to previous PRP kits you have used?

PrecisePRP requires less work and time. Certainly, PrecisePRP does not require a clean blood draw, which is harder in some small patients, nor is there the risk of the sample clotting and wasting/losing a whole kit. When you take a centrifuge out of the equation, you don’t have to worry about matching/balancing/spinning or technical challenges with the filtration kits. PrecisePRP is also nice with a small or an anemic patient so you don’t have to take their blood.

How do you select patients for PRP?

I recommend PRP in all of the cases listed in #1. For ortho cases, a lot of owners find stem cell therapy cost prohibitive, but they want to do something to help accelerate healing and minimize arthritis, so they do PRP.

 

Click the image below to watch the full interview where Dr. Christiansen goes into depth about his use of PRP and why he likes PrecisePRP!

Recently, the VetStem sales and marketing team attended two veterinary shows. One team was in Lexington, KY at the International Society of Equine Locomotor Pathology (ISELP) Proximal Forelimb and Neck Connection module while the other team was in Nashville, TN at the Fetch Nashville conference. At both shows, we were excited to announce that our platelet-rich plasma (PRP) products, PrecisePRP™ Canine and PrecisePRP™ Equine, have completed FDA review.

PrecisePRP™ is intended to provide a species-specific source of concentrated platelets in plasma for intra-articular administration and is unlike any PRP mechanical kit currently on the market. PrecisePRP™ is a freeze-dried, donor-derived (allogeneic) platelet-rich plasma product. Unlike mechanical PRP kits, PrecisePRP™ does not require a blood draw or centrifugation, nor refrigeration, making it a truly off-the-shelf product that is easy and convenient.

Perhaps more important is the uniformity and consistency that PrecisePRP™ provides with its unique patent pending manufacturing process. Each vial of PrecisePRP™ contains a consistent dose of 4 billion platelets per vial at a concentration of 500,000 platelets per microliter and is leucoreduced with less than 1500 white blood cells per microliter. Additionally, each lot is quality tested before release.

According to the FDA, PrecisePRP™ Canine and PrecisePRP™ Equine are the only FDA-reviewed PRP products for dogs and horses available to veterinarians. Both products underwent thorough evaluations by the Center for Veterinary Medicine that resulted in formal risk reviews. According to the FDA, “the developer of PrecisePRP properly identified and appropriately mitigated the potential risks associated with the product, and the FDA has no additional safety concerns.”

Understandably, veterinarians are very excited about these new products. PrecisePRP™ is not only easy, it’s also consistent, allowing veterinarians to know that the PRP they are injecting has been quality tested for sterility, platelet count, and potency. In providing a more consistent product and what is believed to be a therapeutic dose of PRP, the goal is to achieve more favorable outcomes. To learn more about PrecisePRP™, visit our website.

Platelet-rich plasma has been used in veterinary medicine for over 20 years. It is commonly used to treat musculoskeletal diseases and injuries such as osteoarthritis and injured tendons and ligaments. It has also been used topically for wounds and corneal ulcers as well as several other indications. The principle of PRP therapy is to accelerate lagging internal healing processes by amplifying the biological signals that would naturally occur when platelets aggregate at a site of injury. By concentrating platelets and releasing more of those growth factors than would naturally occur, the intended effect is to attract stem cells and other healing cells to stimulate local tissue repair processes.

This week, we are debuting our latest product, PrecisePRP™, at the Fetch DVM360 veterinary conference in Kansas City, MO. This is our first conference since we launched the product, and we are very excited to get in front of veterinarians and technicians to explain what a game-changer PrecisePRP™ is for the industry!

Platelet-rich plasma (PRP) is defined as concentrated platelets in plasma. It is a therapeutic regenerative medicine modality that is commonly used to treat joint disease, such as osteoarthritis, as well as soft tissue injuries (tendon, ligament), and wounds. Unfortunately, there are several variables that can affect the concentration of platelets used for treatment, which can then affect the treatment outcome.  

How is PRP Produced?

Platelet-rich plasma is most frequently produced in the veterinary clinic using a pet’s own blood. The blood is drawn from the patient then filtered or centrifuged using a mechanical PRP kit. There are several mechanical PRP kits on the market currently, each of which requires a unique processing method. Once the blood is run through the kit, the end result is PRP, which is then injected directly into the problem area (i.e., joint, tendon lesion, wound, etc.).

Disadvantages of Mechanical PRP Kits

There are several disadvantages that come with producing PRP using a mechanical kit. Perhaps the most significant of these is the variability of the final PRP used to treat the patient. Numerous factors can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. Ultimately, if the PRP doesn’t contain what is considered a therapeutic dose of concentrated platelets, the patient likely won’t experience much relief.

This variability was made apparent when, in researching PRP kits, we performed a comparison of four PRP kits for the production of equine PRP. Each kit demonstrated a lack of uniformity relating to the final platelet count and platelet concentration. Moreover, each kit failed to meet their respective platelet concentration claim.

Consistency with PrecisePRP™

We didn’t feel comfortable selling PRP kits that would potentially lead to poor treatment outcomes. So instead, we invented PrecisePRP™, a freeze-dried donor-derived platelet-rich plasma currently available in a dog and horse format. PrecisePRP™ Canine and PrecisePRP™ Equine do not require processing to produce PRP, instead your veterinarian will simply rehydrate and inject.

Each vial of PrecisePRP™ undergoes rigorous quality testing to meet precise product release specifications. This results in a uniform and consistent PRP product, eliminating the variability mentioned above so that veterinarians know exactly what they’re injecting every single time. PrecisePRP™ donors are screened according to FDA Center for Veterinary Medicine guidance and in controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™.

Veterinarians interested in purchasing PrecisePRP™ should contact Customer Service.

While we primarily focus on stem cells, another exciting tool in the regenerative medicine bucket is platelet-rich plasma (PRP). PRP is defined as concentrated platelets in plasma. But what does PRP do and what can it be used to treat?

The Healing Properties of Platelets

To understand how PRP works, we first need to understand what platelets do in the body. Platelets are very small cells found in the blood stream of mammals and are best known for their ability to clot the blood. However, there is much more that these tiny but powerful cells can do. A complex signaling system sent out from damaged cells attracts platelets to an injury and tells them to release several healing molecules that they have stored inside of them. In turn, these healing molecules attract a multitude of additional healing cells (including stem cells) to the site of injury or inflammation. Together, these cells have been shown to reduce pain, remove the damaged cells, build new blood vessels, prevent further tissue damage, and generate new healthy cells in place of the injured ones.

What can PRP be Used to Treat?

In veterinary medicine, PRP is most often used for orthopedic problems such as cruciate ligament tears, osteoarthritis, and tendon injuries in dogs, cats, and horses. However, recent research has shown that PRP can also aid in the healing of skin wounds, corneal (eye) ulcers, surgical incision sites, tooth sockets following extraction, and even muscle tears. Platelet therapy can also be used in conjunction with VetStem Cell Therapy to maximize the effect of both treatments.

PRP Kits: How they Work and the Associated Disadvantages

Historically, PRP has been produced using the patient’s blood. The blood is run through a mechanical device, or kit, each of which requires a unique processing method. The end result is concentrated platelets in plasma (PRP), however the exact concentration of platelets in the final product is not usually known.

This is perhaps the biggest disadvantage when using kits to produce PRP. There are several variables that can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. In a recent comparison of four PRP kits for the production of equine PRP, these kits demonstrated a lack of uniformity relating to the final platelet count and platelet concentration, and each kit failed to meet their respective platelet concentration claim.

Consistency is Key: PrecisePRP™

Fortunately, VetStem found a way to significantly reduce these disadvantages. PrecisePRP™ is a freeze-dried, donor-derived platelet-rich plasma; truly an off-the-shelf PRP. Each vial of PrecisePRP™ is uniform in platelet characteristics and concentration. This eliminates the variability mentioned above so that veterinarians know exactly what they’re injecting every single time, which can increase positive treatment outcomes. Additionally, PrecisePRP™ is not a kit and does not require processing, making it an easy and convenient alternative to currently available PRP kits.

We took the development of this product very seriously to ensure a positive safety profile. All donors are screened according to the FDA CVM guidance 254. Each batch is sterility, endotoxin, and quality tested to meet precise product release specifications. In controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™. This unique product is currently available in both dog and horse formats.

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Pretty exciting stuff! Want to learn more? Visit www.vetstem.com/pprp.php for more information.