This week, we are debuting our latest product, PrecisePRP™, at the Fetch DVM360 veterinary conference in Kansas City, MO. This is our first conference since we launched the product, and we are very excited to get in front of veterinarians and technicians to explain what a game-changer PrecisePRP™ is for the industry!

Platelet-rich plasma (PRP) is defined as concentrated platelets in plasma. It is a therapeutic regenerative medicine modality that is commonly used to treat joint disease, such as osteoarthritis, as well as soft tissue injuries (tendon, ligament), and wounds. Unfortunately, there are several variables that can affect the concentration of platelets used for treatment, which can then affect the treatment outcome.  

How is PRP Produced?

Platelet-rich plasma is most frequently produced in the veterinary clinic using a pet’s own blood. The blood is drawn from the patient then filtered or centrifuged using a mechanical PRP kit. There are several mechanical PRP kits on the market currently, each of which requires a unique processing method. Once the blood is run through the kit, the end result is PRP, which is then injected directly into the problem area (i.e., joint, tendon lesion, wound, etc.).

Disadvantages of Mechanical PRP Kits

There are several disadvantages that come with producing PRP using a mechanical kit. Perhaps the most significant of these is the variability of the final PRP used to treat the patient. Numerous factors can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. Ultimately, if the PRP doesn’t contain what is considered a therapeutic dose of concentrated platelets, the patient likely won’t experience much relief.

This variability was made apparent when, in researching PRP kits, we performed a comparison of four PRP kits for the production of equine PRP. Each kit demonstrated a lack of uniformity relating to the final platelet count and platelet concentration. Moreover, each kit failed to meet their respective platelet concentration claim.

Consistency with PrecisePRP™

We didn’t feel comfortable selling PRP kits that would potentially lead to poor treatment outcomes. So instead, we invented PrecisePRP™, a freeze-dried donor-derived platelet-rich plasma currently available in a dog and horse format. PrecisePRP™ Canine and PrecisePRP™ Equine do not require processing to produce PRP, instead your veterinarian will simply rehydrate and inject.

Each vial of PrecisePRP™ undergoes rigorous quality testing to meet precise product release specifications. This results in a uniform and consistent PRP product, eliminating the variability mentioned above so that veterinarians know exactly what they’re injecting every single time. PrecisePRP™ donors are screened according to FDA Center for Veterinary Medicine guidance and in controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™.

Veterinarians interested in purchasing PrecisePRP™ should contact Customer Service.

In last week’s blog, we discussed kidney disease in cats and how VetStem Cell Therapy may help. This week, we want to discuss osteoarthritis (OA) in cats so that cat owners know what to watch out for. That’s right, cats get OA too! In fact, a high percentage of cats will get or already have osteoarthritis. According to one study, 91% of cats between 6 months and 20 years old have OA in at least one joint, as proven by X-rays.

National Take your Cat to the Vet Day

But why two cat blogs in a row, you ask? Well August 22^nd is National Take your Cat the Vet Day. This day is meant to bring awareness to the fact that the statistics for feline veterinary care are disparagingly low compared to dogs. According to one recent academic survey, only 20% of cat owners said they took their cat to the vet more than once a year, compared to 35% of dog owners. Additionally, 7% of cat owners said they never seek veterinary care, compared to 2% of dog owners. Likewise, in a targeted survey of pet owners conducted by the AVMA, only 48% of cat owners said they sought routine veterinary care for their cat, compared to 79% of dog owners.

Cats are Masters at Hiding Their Pain

There are likely several reasons for this discrepancy, one of which may be the fact that cats tend to be masters at hiding their pain. This tendency is often linked to survival instincts. In the wild, if a cat shows weakness, this may draw unwanted attention from a predator. But in the domestic cat whose only predator is a half empty bowl of food, this tendency to hide pain just means us owners have a hard time knowing when our cat should be taken to the vet.

Preventative Veterinary Care for Cats

Thus, National Take your Cat to the Vet Day promotes the idea of once-to-twice yearly preventative veterinary exams. These types of routine check-ups are important to maintain a cat’s health. Even if nothing appears to be wrong with your cat, routine examinations by your veterinarian may uncover some ailment that your cat has been hiding. In the same way, routine bloodwork can help your veterinarian monitor for diseases such as kidney failure.

Symptoms of Osteoarthritis in Cats

But back to OA in cats. For years, osteoarthritis in cats has been underdiagnosed when compared to dogs. One reason for this is that cats with OA present with different symptoms than what we see in dogs. Because of their smaller size and natural agility, cats tend to tolerate bone and joint problems better than dogs. But there are specific symptoms to watch out for.

According to the FDA, “Clinical signs of osteoarthritis in cats include weight loss, loss of appetite, depression, change in general attitude, poor grooming habits, urination or defecation outside the litter pan, and inability to jump on and off objects.” Unlike dogs, cats do not commonly present with lameness or limping. Instead, they will be less willing to jump and/or have shorter jumps.

Treatment for Osteoarthritis in Cats

Unfortunately, there are fewer treatment options for cats with OA compared to dogs. Unlike dogs, cats do not tolerate nonsteroidal anti-inflammatory drugs (NSAIDs) or other pain medications very well. While there are some NSAIDs approved for short-term post-operative use in cats, there are currently no veterinary NSAIDs approved for safe, long-term use to control osteoarthritis pain in cats. There are some non-drug options including weight loss for overweight cats, increased exercise, as well as environmental accommodations such as elevated food bowls and more easily accessible litter boxes. But these are not the only non-drug treatment options available.

VetStem Cell Therapy for Osteoarthritis in Cats

VetStem Cell Therapy is a non-drug treatment option for osteoarthritis in cats, dogs, and horses. It can be particularly beneficial for cats, given that effective treatment options to control osteoarthritis pain are extremely limited. Stem cells have shown the ability to directly modulate pain and down-regulate inflammation. Additionally, stem cells can induce repair and stimulate regeneration of cartilage and other joint tissues. The beauty of VetStem Cell Therapy is that we are harnessing your pet’s own healing power, so it can be considered a natural and holistic approach to managing the symptoms of osteoarthritis.

If you are interested in having your pet treated with VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers in your area.

VetStem Cell Therapy, while commonly used to treat orthopedic conditions in dogs and horses, has also been successfully used to treat a number of other diseases. One such disease is kidney disease in cats. Nearly 250 cats have received VetStem Cell Therapy for kidney disease.

Kidney disease is one of the most common causes of sickness and death in cats. Common symptoms can include weight loss, lethargy, variable appetite, and poor coat quality. Some cats may also drink and urinate more, vomit, or have diarrhea.

Unfortunately, treatment options for cats with kidney disease are limited and can be costly. The good news is, based upon our own data as well as the data of others, we believe that stem cells may help improve the symptoms and quality of life in some cats with kidney disease. In fact, a review of a small number of feline patients treated with VetStem Cell Therapy showed that blood kidney values were slightly to moderately improved after treatment.

Anecdotal data from pet owners and veterinarians suggests that treatment with VetStem Cell Therapy helps to improve symptoms associated with kidney disease. Owners have reported improved appetites, weight gain, and increased energy. That being said, more data is necessary regarding the use of VetStem Cell Therapy for cats with kidney disease. Thus, we continue to research the use of stem cells for this condition under one of VetStem’s clinical research programs.

If you think your cat may benefit from treatment with VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of qualified VetStem providers near you.

August 4^th is Assistance Dog Day and next week is International Assistance Dog Week. This is a time to recognize and honor the hard work and selfless love that assistance dogs provide day in and day out. As you probably know, assistance dogs are specially trained to perform specific tasks for people with disabilities. These disabilities can be physical, sensory, psychiatric, intellectual, or mental. There are many types of assistance dogs including guide dogs for the blind, medical and hearing alert dogs, mobility assistance dogs, and more. In this week’s blog, we are going to share a special story about a psychiatric service dog named Max.

Max has been a trained companion for U.S. Army Staff Sergeant Edward Johnson since 2014. Sgt. Johnson, a purple heart recipient, was shot in the head during combat in Iraq in 2006 and was left with a traumatic brain injury. Max helps Sgt. Johnson cope with PTSD and other debilitating ailments related to his injuries.

Unfortunately, Max tore his cruciate ligament in his knee. As a common injury in large breed dogs, cruciate ligament tear is one of the biggest reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs. Additionally, according to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future.

Max was obviously in pain and in need of surgery and other medical procedures. Fortunately, his story made the news and through donations and good will, Max was able to have surgery and treatment with VetStem Cell Therapy. His surgeon, Dr. Jeff Christiansen of Superior Veterinary Surgical Solutions, donated his services and organized donations from several others as well. As an experienced VetStem provider, Dr. Christiansen recommended stem cell and platelet therapy in conjunction with the surgery to aid Max’s healing. VetStem provided a free platelet therapy kit as well as discounted stem cell processing services.

According to Dr. Christiansen, Max recovered completely. But as is common, Max suffered a second cruciate ligament rupture in his other leg just over two years after his first surgery. Once again, Dr. Christiansen and several companies, including VetStem, stepped up to provide this dog with top-notch care. Max received surgery on his other knee in addition to stem cells and platelet therapy. Max once again recovered well and hasn’t required a repeat stem cell treatment since.