VetStem founder and CEO, Dr. Bob Harman, was recently featured on a San Diego-based podcast to discuss all things stem cells, including the current COVID-19 clinical trial developed by our human company, Personalized Stem Cells.

One Medicine: Animal Data Helping People

We have previously blogged about a concept we call “One Medicine,” also known as translational medicine, in which advances in the veterinary field lead to advances in human medicine. In the last year, this notion has really come to the forefront, as we were hit with the COVID-19 pandemic.

It is very common for human scientists and doctors to review data obtained from animals when developing a new drug or technology. In a previous blog, we discussed how animal data was utilized to expedite development of a COVID-19 vaccine. Additionally, evaluation of COVID-19 positive animals has helped researchers understand how the virus functions and how it is transmitted in various species.

Data from VetStem Patients Helps People with COVID-19

VetStem has also joined the ranks in the fight against COVID-19. In fact, it was VetStem’s 15+ years of veterinary stem cell data that led to the development of an FDA approved COVID-19 stem cell clinical trial in human patients. Our human stem cell company, Personalized Stem Cells, Inc., developed and received FDA approval for the clinical trial and then licensed it to Sorrento Therapeutics. The study is well underway and the preliminary results look very promising.

In addition to discussing our contributions to the COVID-19 clinical trial, Dr. Harman also discussed our work with exotics organizations and specifically mentions helping an arthritic Sun Bear at the San Diego Zoo. He gives a bit of history regarding VetStem’s formation, treating his border collie Ben, as well as his own treatment with stem cell therapy for a rotator cuff injury.

Click here to listen to the podcast!

February 22^nd is National Walk Your Dog Day, a day to remind dog owners about the importance of regular exercise such as walking. Studies have demonstrated that regular exercise can actually reduce symptoms of osteoarthritis and contribute to weight loss and weight management.

Link Between Obesity and Osteoarthritis

According to caninearthritis.org, osteoarthritis is the number one medical condition associated with obesity in dogs. Excess weight leads to increased wear and tear on a dog’s joints and can therefore lead to the onset or worsening of osteoarthritis. When a dog’s joints become painful, this often leads to reduced activity. Reduced activity can lead to more weight gain and thus the cycle continues. While it may seem appropriate to restrict activity for dogs with painful joints, the opposite is actually true!

Walking to Reduce Symptoms of Osteoarthritis

Multiple studies have shown that regular exercise can benefit arthritic joints. Regular, low-impact exercise, such as walking, can lead to reduced joint pain and stiffness, weight loss, and increased muscle mass. Experts agree that regular, short-interval exercise is key, as opposed to doing one big activity on the weekends, such as a long hike. Regular exercise may be something as simple as taking a walk daily or on most days.

So now that you know the benefits of walking, let’s all take a walk on National Walk Your Dog Day!   

Note: Your veterinarian is your best resource when it comes to your dog’s health. Your vet can help you determine if your dog is overweight or if your dog has a degenerative joint condition such as osteoarthritis. He/she can also help you formulate an exercise plan tailored specifically to your dog’s needs.

This week, we have a special guest blog about platelet therapy use in veterinary medicine from Dr. Amber Vibert. Dr. Vibert is VetStem’s Safety and Technical Services Veterinarian and has extensive experience in both general and emergency veterinary medicine.

Platelet Therapy in Veterinary Medicine

I’m very excited to have the opportunity to contribute to our blog today! As VetStem’s new clinical veterinarian, I’m here to give you an added layer of information from a medical perspective. Today I’d like to share with you the capabilities of wonderous cells called platelets. You may have heard the term “Platelet Rich Plasma” (PRP) or “Platelet Enhancement Therapy” (PET) and wondered, “What are platelets and how does this treatment work, exactly?” We have showcased several success stories of pets who have received platelet therapy and now it’s time to look at the science behind the medicine and applications for which they can be used.

Good Things Come in Small Packages

Platelets are very small cells found in the blood stream of mammals and are best known for their ability to clot the blood. However, there is SO MUCH MORE these tiny but powerful cells can do! A complex signaling system sent out from damaged cells attracts platelets to an injury and tells them to release several healing molecules that they have stored inside of them. In turn, these healing molecules attract a multitude of additional healing cells (including stem cells) to the site of injury or inflammation. Together, these cells have been shown to reduce pain, remove the damaged cells, build new blood vessels, prevent further tissue damage, and generate new healthy cells in place of the injured ones. Amazing!

What Can These Heroes of Healing Be Used For?

In veterinary medicine, platelet therapy is most often used for treatment of joint-related problems such as cruciate ligament tears, osteoarthritis and tendon injuries in dogs, cats, and horses. However, recent research has shown that PRP/PET can also aid in the healing of skin wounds, corneal (eye) ulcers, surgical incision sites, tooth sockets following extraction, and even muscle tears. And the use of platelet therapy is not just limited to our animal companions. You may have heard of NFL players who have received PRP/PET for tendon/ligament injuries and muscle tears. Platelet therapy can also be used in conjunction with stem cell therapy to maximize the effect of both treatments.

Harnessing the Power of Platelets

The functions of platelets may be complex, but their collection and administration is quite simple. A calculated amount of blood is drawn based on the patient’s size/weight. The blood sample is then either spun in a machine called a centrifuge or injected through a special filter such as VetStem’s V-PET™ gravitational filter system in order to separate the platelets from other blood cells. The final product is a highly concentrated number of platelets suspended in the protein-rich fluid component of the blood called plasma. This solution is then injected (or topically applied as with skin wounds or surgical incisions) to the injury site. And voila! There you have platelet therapy- another way to enhance the body’s own power to heal.

Welcome to February, which happens to be National Cat Health Month. While we should always be mindful of the health and well-being of our pets, February reminds us not to forget about our cats! Statistics from the American Veterinary Medical Association indicate that dogs in the United States visit veterinarians more frequently than cats. There are likely a number of reasons for this, not the least of which is the fact that cats hide pain and illness very well.

Cats are Masters at Hiding Pain and Sickness

Most of us cat owners know that cats tend to appear slightly less domesticated than dogs (or maybe they are just too smart for their own good!). So it comes as no surprise that some of their survival instincts remain intact. One such instinct is this tendency to hide anything that a potential predator may portray as weakness. By masking weaknesses, the cat does not draw unwanted and potentially dangerous attention.

Signs that Something may be Wrong

The good news is, there are some pretty clear signs to look out for to determine if something may be wrong with your cat. One sign of illness in cats is a change in activity level. Many cats will hide when they are not feeling well, which goes back to their instinct to not attract attention from predators. A sick or painful cat might play less and may not be able to jump as high as before. Some other things to look for include changes in appetite, changes in litter box habits, and of course more obvious signs like vomiting, diarrhea, and limping.

Why Veterinary Care for Cats is Important

Just like dogs (and people!), routine check-ups are important to maintain a cat’s health. Even if nothing appears to be wrong with your cat, these routine examinations by your veterinarian may uncover some ailment that your cat has been hiding. In the same way, routine bloodwork can help your veterinarian monitor for diseases such as kidney failure. In diseases like kidney failure, early diagnosis and treatment leads to a better prognosis.

How VetStem Has Helped Cats

There are multiple feline diseases, in limited numbers, that have been successfully treated with VetStem Cell Therapy. Some of these diseases include osteoarthritis (no, it is not just a dog problem!), kidney disease, gingivostomatitis, and inflammatory bowel disease (IBD). For more detailed information about using VetStem Cell Therapy for these conditions, check out our previous blog. If you are interested in stem cell therapy for your cat, we encourage you to speak to your veterinarian or contact us for a list of VetStem providers in your area. February is the perfect month to check in with your cat’s health!