Aug 16, 2024

Back in the Cat Tree: VetStem Helps Cat with Arthritis

Posted by Bob under Cat Arthritis, Cat Stem Cells

We frequently hear about osteoarthritis (OA) in dogs. And for good reason! OA affects approximately 1 in 5 dogs and can greatly reduce a dog’s quality of life. What we don’t hear about as much is osteoarthritis in cats. But, perhaps surprisingly, a high percentage of cats are affected by OA. In fact, according to one study, 91% of cats between 6 months and 20 years old have OA in at least one joint, as proven by X-rays.

Recognizing Arthritis in Cats

Unlike dogs, cats with pain from arthritis do not typically present with symptoms like limping and lameness. Instead, they will be less willing to jump and/or have shorter jumps. You may also notice a loss of appetite and weight loss, depression or a change in general attitude, poor grooming habits, and urination or defecation outside the litter box.

Case Report: Clyde’s Treatment with VetStem Cell Therapy

One example is Clyde, a cat who suffered from arthritis in multiple joints. According to his owner he could not go up and down stairs, his coat was unkempt, and he no longer climbed in the cat tree. His veterinarian recommended treatment with VetStem Cell Therapy. At the time of treatment, Clyde was approximately 15 years old.

To begin the process, Clyde’s veterinarian collected fat during a minimally invasive anesthetic procedure. The fat was shipped to VetStem where it was processed in our laboratory to extract and concentrate Clyde’s stem cells. One dose of Clyde’s own stem cells was shipped back to his veterinarian for intravenous treatment.

Clyde responded wonderfully to VetStem Cell Therapy. According to his owner, he was able to run up and down the stairs and enjoyed playing with his cat siblings. He also began climbing the cat tree again to watch the birds. Additionally, both his appetite and grooming improved, his coat became shiny and smooth once again.

The Important of Regular Vet Visits for Cats

In this instance, Clyde had symptoms that led his owner to pursue veterinary care. But many cats are masters at hiding their pain. As we approach National Take Your Cat to the Vet Day next week, this is a good reminder that cats need routine veterinary care just as much as dogs. And if you think your cat may benefit from treatment with VetStem Cell Therapy, contact us to receive a list of VetStem providers near you.

Clyde

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Mar 19, 2021

Trinity Receives VetStem Cell Therapy for Feline Kidney Disease

Based on 15+ years of data, veterinarians primarily use VetStem Cell Therapy to treat dogs and horses. But cats have also benefited from stem cell therapy. In previous blogs, we have discussed stem cell therapy for various diseases in cats. For a good overview, read this blog.

VetStem Cell Therapy for Feline Kidney Disease

VetStem has processed nearly 400 feline fat samples to provide stem cells. Of these samples, over 50% have been for cats with kidney disease. Unfortunately, kidney failure may be the number one cause of sickness and death in older cats. Yet treatment options are limited and do not cure the disease.

Veterinarians have been treating feline kidney disease with VetStem Cell Therapy for over a decade. And we have seen some promising results! But nothing is as good as hearing about a kitty who experienced those results firsthand. This is Trinity’s story.

Symptoms, Diagnosis, and Treatment Plan

Trinity is a ragdoll cat who was diagnosed with renal failure when she was twelve years old. She had several symptoms including vomiting, not eating, lethargy, weakness, and weight loss. She was uninterested and spent a lot of time hiding. Her mom worked with several vets to find an effective treatment protocol for Trinity, but she continued to feel bad, and her blood kidney values kept going up.

Eventually, Trinity’s mom found Dr. Tamera Cole at The Animal Hospital at Steiner Ranch. Dr. Cole started Trinity on fluids and multiple medications to ease her symptoms and support her kidneys. Though Trinity’s mom noticed improvement, she continued to research additional treatment options.

Treatment with VetStem Cell Therapy

In her research, Trinity’s mom came across VetStem Cell Therapy and brought it up to Dr. Cole. Dr. Cole was already credentialed to perform the VetStem procedure and agreed that stem cell therapy may help Trinity.

She moved forward with the process and collected a sample of fat tissue from Trinity in a minimally invasive anesthetic procedure. The fat was processed at the VetStem laboratory and Trinity’s stem cells were extracted, concentrated, and divided into doses for treatment. Trinity received an intravenous dose of her own stem cells approximately 48 hours after the initial fat collection procedure. She went on to receive a second intravenous dose approximately two weeks later.

A brown and white ragdoll cat sitting in front of a computer looking at the camera
Trinity

Trinity Gets Her Quality of Life Back

After stem cell therapy, Trinity’s owner maintained the previous treatment protocol with fluids and medications. Several months later, Dr. Cole tested Trinity’s blood work which showed no signs of kidney disease!

Her owner continued the treatment protocol and Trinity remained healthy, started eating again, and gained back all the weight she lost and more. Trinity’s mom stated, “I’m so thankful that I’ve been able to spend so many more years with Trinity. She is a continuous blessing in my life and as you can see from the picture, still shows up to work every day at my home office.”

Trinity is among several cats who have benefitted from VetStem Cell Therapy for kidney disease. Based upon data from a small number of feline patients treated with VetStem Cell Therapy, blood kidney values were slightly to moderately improved after treatment. More evaluation is necessary, however these preliminary results suggest that stem cell therapy may be a viable treatment option for cats with kidney disease.

If your cat is suffering with kidney disease, speak to your veterinarian or contact us to receive a list of VetStem providers in your area to determine if VetStem Cell Therapy may help your cat.

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Feb 5, 2021

February is National Cat Health Month

Posted by Bob under Cat Stem Cells, Cats

Welcome to February, which happens to be National Cat Health Month. While we should always be mindful of the health and well-being of our pets, February reminds us not to forget about our cats! Statistics from the American Veterinary Medical Association indicate that dogs in the United States visit veterinarians more frequently than cats. There are likely a number of reasons for this, not the least of which is the fact that cats hide pain and illness very well.

Cats are Masters at Hiding Pain and Sickness

Most of us cat owners know that cats tend to appear slightly less domesticated than dogs (or maybe they are just too smart for their own good!). So it comes as no surprise that some of their survival instincts remain intact. One such instinct is this tendency to hide anything that a potential predator may portray as weakness. By masking weaknesses, the cat does not draw unwanted and potentially dangerous attention.

A grey and white tabby cat lying on blanket to promote National Cat Health Month

Signs that Something may be Wrong

The good news is, there are some pretty clear signs to look out for to determine if something may be wrong with your cat. One sign of illness in cats is a change in activity level. Many cats will hide when they are not feeling well, which goes back to their instinct to not attract attention from predators. A sick or painful cat might play less and may not be able to jump as high as before. Some other things to look for include changes in appetite, changes in litter box habits, and of course more obvious signs like vomiting, diarrhea, and limping.

Why Veterinary Care for Cats is Important

Just like dogs (and people!), routine check-ups are important to maintain a cat’s health. Even if nothing appears to be wrong with your cat, these routine examinations by your veterinarian may uncover some ailment that your cat has been hiding. In the same way, routine bloodwork can help your veterinarian monitor for diseases such as kidney failure. In diseases like kidney failure, early diagnosis and treatment leads to a better prognosis.

How VetStem Has Helped Cats

There are multiple feline diseases, in limited numbers, that have been successfully treated with VetStem Cell Therapy. Some of these diseases include osteoarthritis (no, it is not just a dog problem!), kidney disease, gingivostomatitis, and inflammatory bowel disease (IBD). For more detailed information about using VetStem Cell Therapy for these conditions, check out our previous blog. If you are interested in stem cell therapy for your cat, we encourage you to speak to your veterinarian or contact us for a list of VetStem providers in your area. February is the perfect month to check in with your cat’s health!

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Jun 26, 2020

New Checklist to Help Detect Osteoarthritis Pain in Cats

Posted by Bob under Cat Arthritis, Cat Stem Cells

When we think of arthritis in our pets, most of us immediately think of dogs. We have all heard about or experienced firsthand dogs with arthritic joints. But what about cats? Well, the truth is, osteoarthritis (OA) in cats is a lot more common than you may think. It is estimated that 45% of all cats and 90% of cats over age 10 are affected by arthritis in some way. Unfortunately, feline arthritis tends to go undiagnosed.

Symptoms of OA in Cats

With such a high percentage of cats potentially affected by arthritis, why is the problem underdiagnosed? The most obvious answer is that most pet owners do not know that their cat has OA because the signs are different than in dogs. The typical symptoms we see in dogs such as limping, stiffness, and pain, are generally not present or are much less noticeable in cats with the same ailment. Cats do not present pain in the same way dogs might. For instance, they do not generally vocalize pain and instead of limping, cats might not jump as well or as high. Knowing the signs is key to helping your veterinarian determine if your cat is affected by OA.

New Checklist to Check for Early Signs of OA

Because cats tend to hide their ailments well, researchers set out to develop a new checklist to help both cat owners and veterinarians determine if a cat is affected by pain associated with OA, also knows as Degenerative Joint Disease (DJD). The recent publication analyzed and compiled data from previously conducted studies to develop a short checklist that veterinarians can use to help detect pain associated with DJD. The checklist may also be beneficial for owners who are concerned their cat may have OA.

The compiled data allowed researchers to pare down longer diagnostic questionnaires into six short questions:

  1. Does your cat jump up normally?
  2. Does your cat jump down normally?
  3. Does your cat climb up stairs or steps normally?
  4. Does your cat climb down stairs or steps normally?
  5. Does your cat run normally?
  6. Does your cat chase moving objects (toys, prey, etc.)

What to Do If You Think Your Cat May Have OA

If you answered no to any of the above questions and your cat hasn’t suffered any obvious injury that you know of, this might indicate that your cat may have OA. The first thing to do is make an appointment with your veterinarian to determine the diagnosis. If it is confirmed that your cat has OA, there are several treatment options that may bring your cat relief. The American College of Veterinary Surgeons recommends a multi-modal approach to pain management for arthritic cats. This may include weight management, physical rehabilitation and certain medications. If your cat is prescribed medication for pain, it is important to monitor them closely with your veterinarian to check for adverse side effects.

Stem cell therapy is another natural treatment option for cats with OA. Like dogs, fat is collected from the patient and shipped to the VetStem laboratory. After processing, VetStem will ship your cat’s own stem cells back to the veterinarian in injectable doses. Though the majority of our clinical data is from dogs, cats have responded to VetStem Cell Therapy in a similar way to dogs. Stem cells have shown the ability to reduce pain and inflammation and thereby improve a patient’s quality of life.

If you think your cat may benefit from stem cell therapy, contact us to receive a list of VetStem providers in your area.

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Jun 5, 2020

Success Story: VetStem Cell Therapy for Feline Kidney Disease

We’ve shared many blog posts about treating cats with stem cells. Although we primarily process fat from dogs and horses for VetStem Cell Therapy, we’ve provided cell processing services for over 350 cats. Like dogs, cats may benefit from VetStem Cell Therapy for the treatment of osteoarthritis. Veterinarians have also treated cats for a variety of internal medicine diseases utilizing VetStem Cell Therapy. These diseases include Gingivostomatitis, Inflammatory Bowel Disease, and Chronic Kidney Disease. For more information about stem cell therapy for these conditions, this blog is very helpful: Stem Cells for Cats: An Overview.

One VetStem recipient, a domestic short haired cat name Bender, received VetStem Cell Therapy for kidney disease and had a positive outcome. Bender’s renal issues began when he was four years old. He ingested an unknown poison and ended up in the emergency hospital on IV fluids for seven days. Following this episode, Bender’s bloodwork showed elevated kidney values and he was diagnosed with stage 3 kidney disease.

Bender

Bender’s owner began researching potential treatment options and came across the VetStem website. She requested a list of stem cell providers in her area and was referred to Dr. Mark Parchman of Bend Veterinary Specialty and Emergency Center. Together, Dr. Parchman and Bender’s owner agreed to move forward with VetStem Cell Therapy.

To begin the process, Dr. Parchman collected fat from Bender. This fat was shipped to the VetStem laboratory and aseptically processed to extract Bender’s stem and regenerative cells. These cells were divided into doses and one dose was shipped back to Dr. Parchman for treatment approximately 48 hours after the fat collection. Bender received a series of three intravenous doses one week apart. The rest of his doses were cryopreserved for future treatment.

Approximately six months after his third stem cell injection, Bender’s owner stated that, “By all appearances he seems happy, healthy, playful, and active. Though he has suffered some permanent kidney damage.”

Approximately two years after his initial round of stem cell injections, he received a follow up intravenous injection from his stem cell bank. That was over three years ago and according to his owner he’s still doing well. His owner stated, “Bender is stable with basically high normal values, lots of energy, playful and continues to do very well considering he was so near not surviving. I believe that stem cell treatments have helped his body recover and remain stable over five years later. Thank you VetStem for blazing a trail for my cat.”

Bender is not the only cat with kidney disease to benefit from VetStem Cell Therapy. Other cats have received VetStem Cell Therapy for the treatment of kidney disease and many have experienced positive outcomes. If your cat has kidney disease and you think VetStem Cell Therapy may help, contact us to receive a list of VetStem providers in your area.

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Nov 15, 2019

Stem Cells for Cats: An Overview

Posted by Bob under Cat Arthritis, Cat Stem Cells

A few weeks ago, our sales and marketing team was at the American Association of Feline Practitioners conference in San Francisco, CA.  So, we thought it an appropriate time to discuss stem cell therapy for cats.  This blog will give you an overview of some of the conditions that veterinarians have treated with VetStem Cell Therapy.

Veterinarians have used VetStem Cell Therapy to treat a variety of conditions in their feline patients, one of which is osteoarthritis.  Though we primarily think of dogs when it comes to osteoarthritis, cats are not immune to the disease.  Their symptoms however may be more subdued or even unnoticeable to their owners- cats tend to be masters at hiding their illnesses.  Some signs to look out for include a decreased activity level, an inability to jump to high places, and missing the litterbox.  In addition to osteoarthritis, veterinarians have used VetStem Cell Therapy to treat cruciate ligament injuries and fractures in cats.

Veterinarians also use VetStem Cell Therapy for the treatment of internal medicine and immune-mediated diseases in cats through our Clinical Research Programs.  A large population of VetStem’s feline patients have been treated for Chronic Kidney Disease.  Based upon data from a small number of feline patients treated with VetStem Cell Therapy, blood kidney values were slightly to moderately improved after treatment.  The goal of our current clinical research program for feline Chronic Kidney Disease is to gather additional data and to better understand the effects of stem cell therapy on these cats.

Two additional clinical research programs are for the treatment of feline Gingivostomatitis and Inflammatory Bowel Disease.  Gingivostomatitis is a painful disease that affects the mouth of cats and can lead to full mouth teeth extractions.  Two small studies conducted at the University of California Davis in cats with full mouth teeth extractions showed favorable results after receiving stem cell therapy for this condition. VetStem believes that stem cells may help without cats having to undergo full mouth teeth extractions.  Inflammatory Bowel Disease is a chronic gastrointestinal disorder which can cause diarrhea, vomiting, inappetence, and weight loss.  In a recently published paper, 5 out of 7 IBD cats that were treated with stem cells were significantly improved or had complete resolution of symptoms whereas the 4 control cats had no improvement.  Since this disease can also affect dogs, VetStem is evaluating the use of stem cells in both species with this condition.

Though this is not an all-inclusive list, the above conditions are those that are most commonly treated in cats with VetStem Cell Therapy. As always, if you think your cat may benefit from stem cells, speak to your veterinarian or contact us for a list of VetStem providers in your area.

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Nov 8, 2019

November is Senior Pet Month

Posted by Bob under Dog Arthritis, Dog Stem Cells

It is officially November, which happens to be Senior Pet Month!  We wanted to highlight senior pets in this week’s blog as we all know that senior pets may be more at risk of developing osteoarthritis.  While dogs and cats of all ages may develop osteoarthritis, studies have indicated that senior dogs are more often diagnosed with osteoarthritis, in part due to the age-related break down of joint tissues such as cartilage, ligaments, and bone.

There is also speculation that senior pets are more often diagnosed with osteoarthritis because symptoms become more prevalent as the disease worsens.  Therefore, owners are more likely to notice symptoms such as limping and stiffness as their pet ages, which often leads to a trip to the veterinarian for diagnosis/treatment.

Maverick, a Golden Retriever, was adopted at 8 years old with osteoarthritis.  Fortunately, his new parents sought VetStem Cell Therapy for his condition and he experienced an improved quality of life.

VetStem Cell Therapy Recipient Maverick

It is important to note however that dogs and cats may develop osteoarthritis at any age.  For instance, if a dog is born with joint dysplasia (malformed joints), he is more likely to develop osteoarthritis at a younger age than a dog born with properly formed joints.  One example is Jack who was showing symptoms of osteoarthritis before he was even a year old.

VetStem Cell Therapy Recipient Jack

The good news is, VetStem Cell Therapy has shown to help pets, both young and old, with osteoarthritis.  Stem cells have been demonstrated to regenerate joint tissues and reduce inflammation.  They also have pain blocking mechanisms that may lead to increased comfort for painful pets.  If your pet, no matter their age, has been diagnosed with osteoarthritis or is showing signs of the disease, speak to your veterinarian about the possibility of treatment with VetStem Cell Therapy.  Or contact us to receive a list of VetStem providers in your area.

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Oct 25, 2019

Veterinarian Highlight: Jerrold Bausman, DVM

Posted by Bob under Cat Stem Cells, Dog Stem Cells

This week we’d like to introduce you to a longtime VetStem user, Dr. Jerrold Bausman of VCA Veterinary Specialists of the Valley.  Dr. Bausman received his DVM from Kansas State University after which he completed a small animal surgical internship and residency at Animal Specialty Group in Los Angeles.  While Dr. Bausman’s practice is focused on surgical cases, he frequently treats patients with osteoarthritis using VetStem Cell Therapy.  Dr. Bausman has been utilizing VetStem Cell Therapy since 2007 and has provided VetStem services for nearly 70 patients including our favorite 3-legged mini Aussie, Mandy.  Another memorable patient was a cat named Small, who was treated for a fracture and osteoarthritis.  Small’s family came all the way from India to receive VetStem Cell Therapy.

We recently asked Dr. Bausman a few questions about VetStem Cell Therapy.  See his answers below.

What injuries/ailments do you typically treat with VetStem Cell Therapy?

I primarily treat osteoarthritis.  Next in line to that would be tendinopathies including traumatic rupture, avulsion or tendon laceration repairs.  More specifically – I treat hip arthritis, followed by elbows for OA then I’d say biceps or supraspinatus tendinopathies.

When is a patient not a good candidate for stem cell therapy?

In my opinion a patient is not a good candidate for stem cell therapy if they have an ailment that stem cells will not assist in.  Let me clarify with an example – cranial cruciate ligament tear.  I have some clients that think stem cell therapy will fix the CCL tear.  That patient is not a good candidate for CCL repair with stem cells.  That patient’s stifle will benefit from stem cells – but they are not going to fix the torn ligament.  Aside from that, it’s anesthetic risk.  I have some patients that are excellent candidates for stem cell therapy BUT are such anesthetic/surgical risks that I do not recommend harvesting (fat for stem cell therapy).  In these cases, I would consider PRP.

You’ve been providing VetStem services for over 10 years.  Why is VetStem your go-to stem cell provider?

VetStem is my go-to stem cell provider because in over 10 years I have never had a single bad experience with them.  And that spans the gamut from quality of product, product delivery and patient outcomes through quality of customer service.  You can always count on a friendly helpful person on the phone every time we call.  And lastly innovation.  I love that VetStem is leading the way in regenerative therapy.

Dr. Jerrold Bausman

We appreciate Dr. Bausman taking the time to speak with us about his use of VetStem Cell Therapy.  If you’re looking for a VetStem provider in the Los Angeles area, contact VCA Veterinary Specialists of the Valley for a consult.

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Aug 30, 2019

Veterinarian Highlight: Kim Carlson, DVM, DACVS

Posted by Bob under Cat Stem Cells, Dog Stem Cells

This week, we would like to introduce you to one of VetStem’s most prolific users: Dr. Kim Carlson. Dr. Carlson practices in the Bay Area of California and recently opened her new surgical practice North Peninsula Veterinary Surgical Group in San Mateo, CA.  Dr. Carlson is a board-certified surgeon with a special interest in orthopedic surgery, oncologic surgery, trauma and wound management.

Dr. Carlson became credentialed to perform VetStem Cell Therapy in 2007 and has provided VetStem services for over 200 patients since!  Dr. Carlson also uses the Pall Veterinary Platelet Enhancement Therapy kit.  We asked Dr. Carlson a few questions about her use of VetStem Cell Therapy.  See her answers below.

Many of your stem cell patients receive VetStem Cell Therapy in conjunction with orthopedic surgery.  Do you recommend stem cell therapy with all of your orthopedic surgeries?  If so, why? 

Yes, I do.  Because of the regenerative power of stem cells.  Most patients having orthopedic surgery have some degree of OA or soft tissue injury.  The benefit of stem cell therapy is faster healing, more normal healing, decreased pain, reduced development of OA.  Stem cells have the ability to treat injuries and return patients to full function that didn’t have a good prognosis with traditional options.  Not only do I recommend stem cell therapy for my orthopedic patients but I also recommend stem cell therapy for my patients who are being treated with skin grafts or other wound treatments.

Please explain why VetStem is your go-to stem cell provider. 

Simple.  Quality control.

You have provided VetStem services for well over 200 patients.  What advice can you offer to pet parents who are considering stem cell therapy for their pet? 

It’s a great option.  I’ve treated two of my own pets.  If you don’t have pet insurance look into obtaining pet insurance that will cover stem cell therapy should you need it for your pet.  Not only can stem cells help your pet with their current injury but their cells will be banked for any potential future treatments.

If you’re located in the Bay Area and are considering stem cell therapy for your pet, Dr. Kim Carlson is a very experienced and knowledgeable surgeon and VetStem provider.

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Apr 12, 2019

Guest Blog: Stem Cells for Inflammatory Bowel Disease

This week, we would like to share a guest blog from one of our veterinary clients, Dr. Joel Stone.  Dr. Stone is a feline practitioner at All Cat Clinic in Englewood, CO.  He received his DVM from Colorado State University in 1990 followed by his PhD from the University of California, Davis in 1995.  Dr. Stone has been credentialed to perform VetStem Cell Therapy since 2010.  Below he describes his experience with one of his stem cell patients, a cat named Adobe.  Adobe was treated under one of VetStem’s clinical research programs for Inflammatory Bowel Disease (IBD).

When I was in High School, I had an awesome teacher named Craig Cogswell.  One of the discussions his students would have every week, was to tell the class if anything “Good and New” had happened in the life of his students in the prior week.  I am not sure why this has stuck with me for all these years (I am not sure I can tell you about anything else I learned in the class), but I have always tried to appreciate anything in my life that is “good and new.” As a veterinarian, you learn new things almost every day.  I want to tell you about a case that I would describe as good and new.

Adobe is an 8-year-old, female neutered domestic medium hair cat that I had initially seen on June 14th, 2016 (when she was 5 years old).  Adobe and her owners, Pam and Paul, had come to the All Cat Clinic to get a second opinion on why Adobe would vomit nearly every day.  She had been on prednisolone once a day for the previous 2 years to treat inflammatory bowel disease (IBD), but Adobe still was vomiting nearly every day.   To be honest with you, this is not necessarily an unusual case.  Cats can vomit for many different reasons. After ruling out bacterial, viral and parasitic reasons for vomiting, I started by trying to determine if she had a food allergy that was making her vomit.  I asked her owners to feed a sample of a diet called Z/D, gave an anti-inflammatory injection that lasts about 7 days and asked the owners to get back with me in about a week.  Her owners said that she did great for about 2 weeks without vomiting but would not eat the Z/D diet.  Adobe’s owners are retired and travel frequently so they asked if I could give a similar medication that lasted longer.  After performing blood work and a urine analysis to rule out reasons for vomiting that are not related to IBD, I agreed to give an injection of a drug called Depo-Medrol (methylprednisolone).  I also suggested another hypo-allergenic diet called the HP diet.  After a few weeks, the owners were happy to report that Adobe liked the HP diet and felt it reduced vomiting and along with the Depo-Medrol injection eliminated vomiting for about 1 month.

From a veterinarian perspective, this is good and bad.  It is good that Adobe finally had some relief from persistent vomiting, but it is bad that this is a treatment that can cause harm, particularly when given repeatedly.  It is known to cause diabetes and a heart condition called hypertrophic cardiomyopathy, that I wanted to avoid.  Therefore, I started recommending alternative drugs that reduced this risk, but still relieved the vomiting.  The problem I faced was that Adobe does not like to take oral medications.  After attempting several alternative medications, we were forced to fall back to giving the injectable drug Depo-Medrol, which we did monthly for about 2 years.  Adobe started showing clinical signs of diabetes after receiving steroidal medication for 4 years – 2 years on prednisolone daily and 2 years on Depo-Medrol monthly.  Her blood glucose was moderately elevated, and she started having glucose in her urine.  Clearly, we needed to do something different.

I had read about a newer treatment involving the use of mesenchymal stem cells (MSC) to treat inflammatory bowel disease that had shown promise.  A published paper had shown that 5/7 cats with IBD were significantly improved or had complete resolution of clinical signs whereas the controls had no improvement (1).  A canine IBD study reported 9/11 dogs had clinical remission (2).  These data support the idea that adult stem cells could provide the immunoregulation necessary to control IBD in cats and dogs.

I discussed this option with Pam and Paul who agreed to let me surgically collect 94.5 grams of adipose tissue from the abdomen and ship the fat to San Diego to process this fat tissue at a company called VetStem.  They isolated 25.4 million mesenchymal stem cells (MSC) from the fat I had sent them, then sent these cells a day later to the All Cat Clinic in Colorado to slowly inject the cells intravenously into Adobe.  The procedure corresponded with the time that Adobe would have received the Depo-Medrol, which we did not give.

The owners reported that the week following the MSC injection, Adobe’s attitude was much improved.  Being the week beyond the time that Adobe usually received the Depo-Medrol, the improvement seen in Adobe’s behavior is significant.  Adobe was not acting “sickly”, wasn’t cowering, wanted to be petted by the owners and had a good appetite. Adobe had 3 episodes of vomiting the 1st week following the MSC injection, but these episodes included small amounts of whole food instead of large digested kibble.  Starting the second week post-MSC injection, Adobe started showing signs of lethargy, was quiet, and eating less food.  On Nov. 14th, a repeat blood panel and urine analysis was performed which was normal, except for mild renal insufficiency.  The hyperglycemia and glucosuria was resolved.  Subcutaneous fluids, along with famotidine, mirtazapine and Cerenia were given.  Adobe was also treated for mild/moderate ear infection and mild conjunctivitis.  Adobe responded well to the appetite stimulants, anti-nausea, ear, eye and fluid therapy treatments and a second MSC injection was scheduled.

On Nov. 28th, a second MSC injection was given.  Following this injection, Adobe improved significantly.  Owner stated that Adobe was acting like a younger version of herself, no vomiting was seen and had a good appetite.  Two weeks following the 2nd injection of MSC and 3 months since the last Depo-Medrol injection, Adobe was reported to be doing extremely well.  The only major concern was that Adobe’s hair appeared to be thinning.  The literature reveals the opposite effect with hair growth usually occurring after MSC injections.  It is possible that after such a long period of steroid treatment that hair loss might be a response to withdrawal and subsequent cellular “normalizing” prior to hair regrowth.

Currently Adobe is doing very well.  She has not been vomiting for about 4 months.  We haven’t needed to treat the chronic vomiting with methylprednisolone (Depo-Medrol) since starting the MSC therapy.  Adobe had alopecia/hair thinning for about 2 months after the MSC therapy, but most recently, has regained her normal hair coat.

From my perspective, this treatment can be categorized as “new and good.”  It is a little early to know just how good this new treatment modality will be in clinical practice, but as new cases present themselves and we gather more information, my hope is that we will be able to say that MSC treatment is “new and very good!”

 

1)  Webb, TL and Webb, CB.  Stem cell therapy in cats with chronic enteropathy:  a proof-of-concept study.  J Fel Med and Surg (2015) 17 (10):901-908.

2)  Perez-Merino E.M., Uson-Casaus J.M., Zaragoza-Bayle C., Duque-Carrasco J., Marinas-Pardo L., Hermida-Prieto M., et al.  Safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease:  Clinical and laboratory outcomes.  Vet J (2015) 206(3), 385-390.

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