Did you know that cruciate ligament rupture is one of the most common reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs? While there are multiple treatment options available, both surgical and non-surgical, treatment with stem cells may accelerate and improve healing within the joint. Numerous dogs have received VetStem Cell Therapy for cruciate ligament injuries. Generally speaking, stem cells are more effective when the ligament is only partially torn. In many cases, a full tear will still require surgery.

Leo’s Stem Cell Story

Leo is a 92-pound German Shepherd. One day, after jumping out of his owner’s SUV, he yelped and held his right rear leg up. Two veterinarians confirmed that Leo had partially torn his cruciate ligament in his right knee. While dogs of any size can be affected by this injury, large breed dogs tend to be more at risk.

Initially, Leo’s owners took a conservative approach to manage his condition. Non-surgical treatment usually involves some combination of anti-inflammatory and pain medications, exercise modifications, joint supplements, rehabilitation, and possibly braces/supports. Unfortunately, conservative medical management is not always successful, and after months of leash walks only, Leo’s symptoms worsened.

VetStem Cell Therapy for Cruciate Ligament Tear

After months of research, Leo’s owners elected to try VetStem Cell Therapy as opposed to surgical repair of the injured ligament. Stem cells are regenerative cells that can reduce pain and inflammation, reduce the formation of scar tissue, help to restore range of motion, and stimulate regeneration of tendon, ligament, and joint tissues. Additionally, according to surveys answered by owners and veterinarians, greater than 80% of dogs showed an improved quality of life after receiving VetStem Cell Therapy for orthopedic conditions.

To begin the process, Leo’s veterinarian, Dr. Chris Forstall of SouthShore Animal Hospital, collected fat tissue from his abdomen during a minimally-invasive anesthetic procedure. The cells were aseptically packaged and shipped to the VetStem processing laboratory. Lab technicians processed the fat to isolate and concentrate the stem and regenerative cells contained therein. These cells were packaged into separate stem cell doses, two of which were shipped to Leo’s veterinarian for treatment, while the rest were put into cryopreservation for potential future use.

Approximately 48 hours after the initial fat collection, Leo received one injection of his own stem cells into each knee. You may be wondering why Leo’s veterinarian injected both knees, as opposed to just his injured knee. According to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future. Because of this, many veterinarians choose to treat both knees with stem cells, even when there is only one injured knee. This prophylactic approach may reduce or delay the possibility of injuring the second knee.

Leo Improves after VetStem Cell Therapy

According to his owner, Leo showed improvement just one month after treatment. His owner stated, “Leo is improving every day. We are thrilled that VetStem banked Leo’s stem cells for future use. I’m looking forward to him improving even more. Thank you for offering this cutting-edge therapy!”

Leo’s initial stem cell process yielded several additional doses that are currently cryopreserved. Cryopreservation of stem cells allows them to maintain their functional properties so that they can be used in the future should Leo require them.

If your dog has suffered from a partial cruciate ligament tear, speak to your veterinarian about the possibility of treatment with VetStem Cell Therapy. Or contact us to find a VetStem provider near you.

Cruciate ligament rupture is one of the most common reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs. Additionally, according to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future. While there are multiple treatment options available, both surgical and non-surgical, treatment with stem cells may accelerate and improve healing within the joint.

Risk Factors for Cruciate Ligament Rupture

Unfortunately, no dog is completely safe from a cruciate ligament tear. However, there are certain risk factors that make cruciate ligament tears more likely. The cause of canine cruciate tears is likely multi-factorial and include breed, activity level, reproductive status, body weight, body condition, conformation, and even immune system variables. Canine cruciate ligament rupture ultimately results in degradation of the joint structures which leads to degenerative joint disease and osteoarthritis.

Treatment Options for Cruciate Ligament Tears

There are several treatment options for cruciate ligament tears which may depend on the severity of the injury. Common treatment recommendations include rest, nonsteroidal anti-inflammatory drugs (NSAIDs), physical rehabilitation, and surgical repair. While surgery may be indicated for complete tears, partial tears can sometimes heal without surgical intervention. Unfortunately, degradation of the joint and subsequent osteoarthritis will likely still occur with or without surgery.

VetStem Cell Therapy for Cruciate Ligament Injuries

The goal of using VetStem Cell Therapy for cruciate ligament tears in addition to surgery and other standard treatments is to halt or reduce the progression of osteoarthritis and thereby improve the dog’s condition long-term. By halting or reducing the development of osteoarthritis in the knee, a dog will experience less discomfort and better functional ability. Stem cells help to achieve this by migrating to areas of inflammation and reducing inflammation, stimulating tissue repair, and reducing scar tissue formation.

If your dog has experienced a cruciate ligament tear, speak to your veterinarian about the possibility of treatment with VetStem Cell Therapy. Or contact us to receive a list of VetStem providers near you.

Unfortunately, it’s not an uncommon story. A dog is running and playing and suddenly starts limping or holding one of their back legs up as if hurt. Usually, a trip to the veterinarian is in order. That’s exactly what happened to Belle, a mixed-breed dog, who was approximately 9 years old when she injured her knee. A trip to her veterinarian revealed that she had partially torn her cruciate ligament and also had osteoarthritis in her left knee.

Cruciate Ligament Injuries in Dogs

Cruciate ligament rupture is one of the most common reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs. Additionally, according to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future. While there are multiple treatment options available, both surgical and non-surgical, treatment with stem cells may accelerate and improve healing within the joint.

VetStem Cell Therapy for Partial Cruciate Ligament Tears

Though full cruciate ligament tears often require surgical repair, partial tears can sometimes be treated successfully without surgery. Stem cells are regenerative cells that can differentiate into many tissue types, reduce pain and inflammation, help to restore range of motion, and stimulate regeneration of tendon, ligament, and joint tissues. Many dogs have received VetStem Cell Therapy for partial cruciate ligament tears and have experienced a better quality of life. Thus, Belle’s veterinarian, Dr. Jennifer Tate of Timberstone Vet, recommended treatment with VetStem Cell Therapy.

Belle Receives Treatment with VetStem Cell Therapy

To begin the process, Dr. Tate collected fat tissue from Belle’s abdomen during a minimally invasive anesthetic procedure. The fat tissue was shipped to the VetStem laboratory where lab technicians extracted and concentrated Belle’s stem and regenerative cells. Two stem cell injections were shipped to Dr. Tate for treatment while the rest were put into cryostorage. Approximately 48 hours after the initial fat collection procedure, Belle received one stem cell injection into her affected knee as well as one intravenous injection.

According to her owner, Belle had a great response to treatment with VetStem Cell Therapy. Her owner stated, “Choosing to do stem cell therapy for Belle was the best choice we could’ve made. Within a few months of treatment and recovery, she was back to her old self running and playing and patrolling her kingdom.” Approximately one year later, Belle received a similar stem cell treatment for her opposite knee. Using some of her stored stem cell doses from the initial procedure, Belle received one dose into her right knee and one intravenous dose. She recovered well from that procedure and, according to her owner, is a happy girl with great mobility.

If your dog has an injured cruciate ligament, speak with your veterinarian about the possibility of treating with VetStem Cell Therapy. Or contact us to receive a list of VetStem providers in your area.

We always get excited when one of our clients reaches a stem cell milestone and we recently announced that Dr. Kim Carlson, a small animal surgeon based in the Bay Area of Northern California, surpassed 300 stem cell processes! She is the first small animal veterinarian to achieve this number of VetStem patients.

Dr. Carlson is a board-certified surgeon who has been utilizing VetStem Cell Therapy since 2007. As one of VetStem’s most prolific users, Dr. Carlson consistently advocates for the integration of stem cell therapy in conjunction with orthopedic surgeries such as cruciate ligament repairs, luxating patella surgery, and fracture repairs.

Many of Dr. Carlson’s patient’s experience great success after treatment with VetStem Cell Therapy, including Oliver, a young Shih Tzu who was successfully treated with stem cells in conjunction with surgery for arthritis in his elbows. One of Dr. Carlson’s most memorable stem cell success stories was that of a search and rescue K9, Yana, who was able to return to work after receiving VetStem Cell Therapy for a partial iliopsoas tear.

Stem cells, with their regenerative capabilities and ability to differentiate into various tissue types, play a pivotal role in reducing pain, inflammation, and the formation of scar tissue. Additionally, they aid in restoring range of motion and stimulating the regeneration of tendon, ligament, and joint tissues. VetStem is proud to partner with veterinarians like Dr. Kim Carlson to provide solutions for animals facing degenerative diseases like osteoarthritis and traumatic injuries such as torn ligaments and injured tendons.

As we wrap up Animal Pain Awareness Month, we wanted to share a VetStem Cell Therapy success story. As you may remember from last week’s blog, stem cells have the ability to directly modulate pain, thereby leading to increased comfort and an improved quality of life. This particular patient was treated by the President-Elect of the International Veterinary Academy of Pain Management, Dr. Douglas Stramel. Dr. Stramel, who owns and practices at Advanced Care Veterinary Services, is the first and only Certified Veterinary Pain Practitioner in the Dallas/Fort Worth area.

As the President of IVAPM, Dr. Stramel takes pain management very seriously and has made it a primary focus of his veterinary practice. He employs advanced multi-modal pain management protocols including physical therapy, acupuncture, shock wave, laser therapy, and, you guessed it, regenerative medicine. Dr. Stramel has been a longtime user of VetStem Cell Therapy and has treated nearly 50 patients. Thus, when Kim, a German Shepherd and trained agility dog, presented with a partially torn cruciate ligament, he recommended treatment with stem cells.

To begin the VetStem process, Dr. Stramel collected a sample of fat tissue from Kim’s abdomen during a minimally invasive anesthetic procedure. The fat was shipped to the VetStem laboratory where technicians processed the fat to extract and concentrate the stem and regenerative cells contained therein. Three doses were prepared and shipped to Dr. Stramel for injection and the rest of Kim’s cells were put into cryopreservation for potential future use. Approximately 48 hours after the initial fat collection procedure, Kim received an injection of her own stem cells into each knee as well as an intravenous injection.

According to her owner, Kim had a great response to stem cell therapy and her knee is still doing well. She was even able to return to competition! Her owner stated, “Kim’s stem cell injection has provided her an opportunity to live her best life. We decided to change sports, so she now does AKC Rally and UKC Nosework. She continues with rehab to keep her knee in the best possible shape. Her rehab includes cold laser, underwater treadmill, and acupuncture therapy every 2-3 months.”

While stem cells have many mechanisms of action, studies focusing on the ability to directly affect acute and chronic pain have been relatively recent. Stem cells can also down-regulate inflammation and contribute to tissue regeneration, all of which helped to get Kim feeling better.

If you think your pet may benefit from VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers near you.

We’re back with another pain-themed blog for Animal Pain Awareness Month. This week, we are discussing VetStem Cell Therapy as a means to control pain in pets. While stem cells have many mechanisms of action including the ability to differentiate into many tissue types and stimulate the regeneration of tendon, ligament, and joint tissues, they also have the ability to reduce pain and inflammation.

The ability of stem cells to down-regulate inflammation is important when it comes to pain management. Through cellular communication, stem cells are able to limit inflammatory responses and actually shift from a pro-inflammatory environment to an anti-inflammatory environment. By reducing inflammation, stem cells promote healing and increased comfort.

While a reduction in inflammation can lead to increased comfort, current literature supports that stem cells also have the ability to address both acute and chronic pain directly. Stem cells have shown to secrete pain blocking cytokines (small proteins), which can have opioid-like effects. Interestingly enough, these effects can actually be reversed by Naloxone, an opioid antagonist.

This helps to explain why we consistently hear from pet owners and veterinarians alike that patients treated with VetStem Cell Therapy for things like osteoarthritis or injured cruciate ligaments, experience increased comfort within just days of receiving treatment. By directly decreasing the pet’s pain, their comfort level goes up while the stem cells continue to perform their healing duties.

Thousands of animals have experienced a better quality of life as a result of treatment with VetStem Cell Therapy. Stem cells have the advantage of being a readily available, natural source of anti-inflammatory and pain blocking cells. This can be especially beneficial for cats and some dogs who do not tolerate pain medications well. If you think your pet may benefit from VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers near you.

August 4^th is Assistance Dog Day and next week is International Assistance Dog Week. This is a time to recognize and honor the hard work and selfless love that assistance dogs provide day in and day out. As you probably know, assistance dogs are specially trained to perform specific tasks for people with disabilities. These disabilities can be physical, sensory, psychiatric, intellectual, or mental. There are many types of assistance dogs including guide dogs for the blind, medical and hearing alert dogs, mobility assistance dogs, and more. In this week’s blog, we are going to share a special story about a psychiatric service dog named Max.

Max has been a trained companion for U.S. Army Staff Sergeant Edward Johnson since 2014. Sgt. Johnson, a purple heart recipient, was shot in the head during combat in Iraq in 2006 and was left with a traumatic brain injury. Max helps Sgt. Johnson cope with PTSD and other debilitating ailments related to his injuries.

Unfortunately, Max tore his cruciate ligament in his knee. As a common injury in large breed dogs, cruciate ligament tear is one of the biggest reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs. Additionally, according to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future.

Max was obviously in pain and in need of surgery and other medical procedures. Fortunately, his story made the news and through donations and good will, Max was able to have surgery and treatment with VetStem Cell Therapy. His surgeon, Dr. Jeff Christiansen of Superior Veterinary Surgical Solutions, donated his services and organized donations from several others as well. As an experienced VetStem provider, Dr. Christiansen recommended stem cell and platelet therapy in conjunction with the surgery to aid Max’s healing. VetStem provided a free platelet therapy kit as well as discounted stem cell processing services.

According to Dr. Christiansen, Max recovered completely. But as is common, Max suffered a second cruciate ligament rupture in his other leg just over two years after his first surgery. Once again, Dr. Christiansen and several companies, including VetStem, stepped up to provide this dog with top-notch care. Max received surgery on his other knee in addition to stem cells and platelet therapy. Max once again recovered well and hasn’t required a repeat stem cell treatment since.

While we primarily focus on stem cells, another exciting tool in the regenerative medicine bucket is platelet-rich plasma (PRP). PRP is defined as concentrated platelets in plasma. But what does PRP do and what can it be used to treat?

The Healing Properties of Platelets

To understand how PRP works, we first need to understand what platelets do in the body. Platelets are very small cells found in the blood stream of mammals and are best known for their ability to clot the blood. However, there is much more that these tiny but powerful cells can do. A complex signaling system sent out from damaged cells attracts platelets to an injury and tells them to release several healing molecules that they have stored inside of them. In turn, these healing molecules attract a multitude of additional healing cells (including stem cells) to the site of injury or inflammation. Together, these cells have been shown to reduce pain, remove the damaged cells, build new blood vessels, prevent further tissue damage, and generate new healthy cells in place of the injured ones.

What can PRP be Used to Treat?

In veterinary medicine, PRP is most often used for orthopedic problems such as cruciate ligament tears, osteoarthritis, and tendon injuries in dogs, cats, and horses. However, recent research has shown that PRP can also aid in the healing of skin wounds, corneal (eye) ulcers, surgical incision sites, tooth sockets following extraction, and even muscle tears. Platelet therapy can also be used in conjunction with VetStem Cell Therapy to maximize the effect of both treatments.

PRP Kits: How they Work and the Associated Disadvantages

Historically, PRP has been produced using the patient’s blood. The blood is run through a mechanical device, or kit, each of which requires a unique processing method. The end result is concentrated platelets in plasma (PRP), however the exact concentration of platelets in the final product is not usually known.

This is perhaps the biggest disadvantage when using kits to produce PRP. There are several variables that can affect the final platelet concentration such as the current health of the patient, platelet count of the patient, operator handling of the sample, and the effectiveness of the kit used to produce the PRP. In a recent comparison of four PRP kits for the production of equine PRP, these kits demonstrated a lack of uniformity relating to the final platelet count and platelet concentration, and each kit failed to meet their respective platelet concentration claim.

Consistency is Key: PrecisePRP™

Fortunately, VetStem found a way to significantly reduce these disadvantages. PrecisePRP™ is a freeze-dried, donor-derived platelet-rich plasma; truly an off-the-shelf PRP. Each vial of PrecisePRP™ is uniform in platelet characteristics and concentration. This eliminates the variability mentioned above so that veterinarians know exactly what they’re injecting every single time, which can increase positive treatment outcomes. Additionally, PrecisePRP™ is not a kit and does not require processing, making it an easy and convenient alternative to currently available PRP kits.

We took the development of this product very seriously to ensure a positive safety profile. All donors are screened according to the FDA CVM guidance 254. Each batch is sterility, endotoxin, and quality tested to meet precise product release specifications. In controlled safety studies of dogs and horses, there were no notable adverse events related to treatment with PrecisePRP™. This unique product is currently available in both dog and horse formats.

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Pretty exciting stuff! Want to learn more? Visit www.vetstem.com/pprp.php for more information.

A sad story that we hear a lot is when a ball-loving dog is no longer able to play fetch due to arthritis or some other orthopedic injury. That was the case for Sherlock, a nearly 100-pound Staffordshire terrier/rottweiler mix. Though Sherlock loved to chase his ball, as he got older, his body started slowing down and he was diagnosed with arthritis in all four limbs. In an effort to not take away his favorite activity, his owners continued to play ball with a little less intensity. And then he tore his cruciate ligament in his right knee.

Fortunately for Sherlock, his veterinarian recommended using VetStem Cell Therapy in conjunction with surgery. Stem cells have the ability to reduce pain, inflammation, and minimize the formation of scar tissue. In addition to his injured knee, Sherlock’s veterinarian treated both of his elbows and his non-injured knee to give him some relief from the arthritis in those joints.

Sherlock’s owner reported that he responded well to his initial stem cell treatment but that shortly after, he injured the cruciate ligament in his left knee. Unfortunately, this is more common than you may think. According to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future. This time, Sherlock’s veterinarian was able to request doses from his stored stem cells, which she administered during the surgery on his left knee. Sherlock once again received an injection of his own stem cells into each knee and each elbow.

After treatment, his owner said that his recovery went from six weeks to three-and-a-half weeks. She stated, “He healed so quickly that it surprised everyone. He was 12 years old by this time and a full recovery seemed almost too hopeful to wish for, but instead we not only got a full recovery but a faster recovery than before.” She went on to state, “Sherlock is now 13 years old and we do not run and chase balls anymore, but we enjoy walks on the beach and lots of snuggles and I am so grateful that he is still here feeling good and enjoying life with me. Stem cell therapy made an immense difference in his ability to live a high quality life in his older years.”

Does your dog suffer from osteoarthritis or have they injured their cruciate ligament? If so, VetStem Cell Therapy may help. Speak to your veterinarian or contact us to receive a list of VetStem providers near you.

As you probably know, much of the VetStem blog is spent discussing the treatment of arthritis with stem cells. We talk about things like joint dysplasia and cruciate ligament tears as catalysts for the development of arthritis. In today’s blog, we are discussing Fragmented Coronoid Process, or FCP, a developmental defect that causes arthritis in the elbows.

Nikolai Augustus, a Labrador retriever, was 2 years old when he began limping. X-rays revealed he had broken bone fragments in both of his elbows as a result of fragmented coronoid process, or FCP. FCP is one of the main diseases associated with elbow dysplasia. It is a developmental defect of the two small bony protrusions on the end of the ulna, known as the coronoid processes, within the elbow joint. In this condition, one of the bony protrusions develops a fissure or crack and separates from the ulna. FCP may result in instability and pain as well as decreased mobility and swelling.

The treatment of choice for FCP is surgical removal of the bone fragments and any abnormal cartilage. This procedure can be performed arthroscopically by an orthopedic surgeon, which results in a smaller incision and less damage to the supporting elbow structures. In all cases however, regardless of surgical repair, the patient will develop some degree of arthritis. That’s where VetStem comes in!

Niko’s veterinarian recommended arthroscopy in addition to treatment with VetStem Cell Therapy. Stem cells are regenerative cells that can differentiate into many tissue types and have demonstrated the ability to reduce pain and inflammation, help to restore range of motion, and stimulate regeneration of tendon, ligament, and joint tissues. By using VetStem Cell Therapy in conjunction with surgery, Niko’s vet hoped to delay the progression and reduce the severity of degenerative joint disease in his elbows.

To begin the process, Niko’s vet collected fat tissue from his abdomen in a minimally invasive anesthetic procedure. The fat was aseptically packaged and shipped to the VetStem processing laboratory in Poway, California. Lab technicians processed the fat to extract and concentrate the stem and regenerative cells contained therein. The cells were divided into doses, and two injectable doses were shipped to Niko’s vet for treatment. Approximately 48 hours after the initial fat collection procedure, Niko received one dose of his own stem cells into each elbow.

According to Niko’s owner, he had a great response to the treatment. His owner stated, “One year after surgery and stem cell therapy and Niko is running and playing with the energy of a 3-year-old. We are thankful our vet recommended stem cell therapy for Niko and that he has the bank of stem cells to help treat Niko in the future.”

In addition to the two stem cell doses that were shipped for immediate treatment, several doses of Niko’s stem cells were put into cryopreservation. This is particularly valuable for a patient like Niko who will never have perfect, arthritis-free elbows. In fact, approximately 15 months after his initial treatment, Niko received a follow up treatment identical to his first using some of his banked stem cell doses. Niko’s additional cells will remain in cryopreservation and can be accessed for treatment as needed for the remainder of his life.

If you think your pet may benefit from treatment with VetStem Cell Therapy, contact us to receive a list of providers in your area.